Biography:

Will be updated soon

Abstract:

Liquid crystals (LC) are a special unique mesophase that combines both the properties of a liquid (viscosity and fluidity) and a solid (anisotropy of the refractive index, diffraction, etc.). From one side, the molecules of liquid crystals with the dimension of ~15 angstroms can be considered as the real nano-objects; from the other side, they can be ordered by the action of the different external fields, including electric field, which allows creating the various electro-optical devices. Electro- and light-addressed spatial light modulators, display elements, biomedical indicators, sensors, etc. can be developed based on the LC mesophase. It should be mentioned that each LC cell includes a direct LC layer, conductive contacts based on indium tin oxides (ITO) or zinc oxide (ZnO), orientation layers, glass or quartz substrates. ITO contacts with the thickness significantly less than the thickness of the LC layer are often destroyed under the influence of intense laser radiation. Changes in the strength parameters of ITO are a problem that can be solved, for example, by various technological approaches, such as: HfO₂ deposition using PDV or CVD methods. Among technical methods, the laser-oriented deposition (LOD) technique occupies a special place. This method permits to deposit the carbon nanotubes (CNTs) directly in the vertical position on the substrate without essential losses of the carbon materials. The advantage of this method is connected with the fact that modified ITO-conducting layers can predict the novel properties.

In the current report based on this novel nanotechnological approach, it is possible to increase the mechanical and laser strength of ITO contacts, dramatically decrease the resistance, and reduce the number of technological operations when developing an LCD device. In addition, it is important to note that ITO contacts are capable of performing two functions: an electric conductor and an orientating layer for the LC molecules. Thus, it is possible to remove a direct orientating high-resistance layer (usually polyimide) from the technological process, reducing the level of the supply voltage applied to the device.

In this paper, a comparative analysis of the physical and technical parameters of pure ITO, ITO structured by hafnium oxides, ITO structured by vertically deposited CNTs is carried out. Preliminarily performed experiments, analytical, and quantum-chemical calculations allow us to expand the field of use of LC cells with modified ITO layers not only for the general purposes of optoelectronics but also for the optical limitation of high-power laser radiation and for the orientation of bio-objects based on DNA and red blood cells.

Biography:

Giorgi Dalakishvili joins Georgian Technical University (GTU) as a Professor in the Department of Hydro Engineering in 2010. Prior to attending GTU, he was a Head of Department of Management, material-technical and social base for the development at Ministry of Education and Science of Georgia. Up to 1996, he was Head of Department at Institute of Structural Mechanics and Earthquake Engineering. He received her MBA from Georgian Technical University and a Ph.D. from the Institute of Structural Mechanics and Earthquake Engineering of the Georgian Academy of Sciences. He has developed new courses as a Professor at GTU. His primary research interests are in the field of Holographic Interferometry and its applications in monitoring and diagnosis of the process of shrinkage and crack formation in concrete. He was a scientific head of some magister and doctoral thesis. Specifically, he is interested in student experimental works, as well as pedagogies. In his free time, he enjoys traveling.

Abstract:

Timing: 09:30:00 to 09:55:00 EDT 

Concrete is the main building material for hydro construction. Therefore, it is very important to study long-term processes, such as shrinkage, creep, swelling, temperature, and crack resistance, which affects its strength. Known methods do not fully describe these processes in materials such as concrete and reinforced concrete. In this paper, an application of holographic interferometry is considered which enables to evaluate qualitatively and quantitatively the deformation of a solid body and the processes of shrinkage, crack formation and development of concretes of different compositions. A holographic plate is exposed twice before chemical processing - for the first time when the surface of the test sample is in the initial condition, and the second time when it is deformed or undergoes any other impact. This is a unique way to simultaneously observe a unified picture of deformation on the whole registered surface of the object understudying and, at the same time, to measure all three components of the displacement vector at any chosen point. Experimental studies are discussed, in particular, such long-term processes as shrinkage and cracking for various fillers and various reinforcing materials. The improvement and development of research methods, as well as a broad introduction of its results in practice, which will further facilitate the reliability and durability of concrete and reinforced concrete structures, one of the major building materials in construction, in particular in hydro-technical construction. This will allows for monitoring and diagnostics during dam construction.

Biography:

Bo Yan, 2000-2004 graduated from Zhejiang University, 2004-2009 Chinese Academy of Sciences, Shanghai Institute of Optics and Fine Mechanics, 2009-2011, University of Science and Technology, postdoctoral, 2011-2015, JILA, University of Colorado, postdoctoral, 2015, national "1000-young " plan, back to Zhejiang University to set up a new lab.

Professor Bo Yan’s research is mainly focused on an experimental study of the ultra-cold atoms, cold molecules, including strongly correlated ultra-cold atomic systems and laser cooling of polar molecules. Prof. Bo Yan has published more than 20 papers, including Nature, Science, Phys. Rev. Lett, the total citation is more than 1300.

Abstract:

By introducing the Raman couplings, Bose-Einstein condensate can be coupled into different momentum states. A lattice in the momentum space can be created by introducing multi-frequency Raman couplings. By engineering the tunneling rates, the detunings, and the relative phase of the couplings in different sites, topological models can be realized and studied experimentally. By switching the couplings on and off, we realize a topological quantum walk of ultracold atoms in the momentum space.

The topological phase transition is mapped out, and the interaction induced localization effect is observed. By introducing the effective loss, a non-Hermitian AB ring is realized, and the non-reciprocal transport behavior is observed.

Biography:

Francesco Dell’ Olio received the M.Sc. degree in electronic engineering (cumlaude) and the Ph.D. degree in information engineering from Polytechnic University of Bari, Bari, Italy, in 2005 and 2010, respectively. Since December 2019, he has been an Assistant Professor at the Polytechnic University of Bari. His research interests include integrated optoelectronics and photonics. He has been involved in several research projects and is the co-author of more than 100 journal articles and conference papers.

Abstract:

Timing: 10:20:00 to 10:45:00 EDT 

In the last two decades, there has been a game-changing transformation of integrated microphotonics. Silicon has become the material of choice to fabricate photonic integrated circuits (PICs) whose complexity is increasing according to Moore’s law.

Silicon photonics components and integrated circuits are typically designed, assuming that the propagating mode is either TE or TM. This is due to the high birefringence of the silicon wires commonly used to guide light within them.

Polarization handling devices improve the performance of the silicon PICs by reducing the polarization-dependent dispersion and loss. In addition, the research interest towards polarization division multiplexed transceivers using PICs in stimulating a quickly growing effort on the technical solutions enabling polarization management on-chip.

The talk overviews the approaches currently utilized for designing efficient polarization handling devices in high-density silicon PICs and discuss the most promising strategies for improving the performance of such devices. A few notes on a new ultralow loss and high extinction ratio silicon TM-pass polarizer are given.

Biography:

Matras Guillaume joined Thales Laser (Orsay, France) in 2004 as a Ph.D. student to develop a high repetition rate Ti:Sa laser system for micro-processing applications in collaboration with Hubert Curien Laboratory (Saint-Etienne, France). He received his Ph.D. in 2008 and continued in the same company to work on several and complex Ti:Sa laser systems (mJ-kHz, TW, and PW systems) for scientific customers, firstly as laser engineers and progressively as the project manager. In 2013, he was called to manage the development and the delivery of the stretchers and compressors of the High Power Laser System for ELI-NP. In 2016, he was appointed as a technical solution leader to ensure the good technical implementation of the laser system in the ELI-NP facility. The HPLS was delivered in October 2019 with full performances. In parallel (2017- 2018), he had the opportunity to work with the ICFO laboratory of Barcelona to develop a mid-IR OPCPA source at 7µm.

Abstract:

We report the generation of unprecedented 10 Peta Watt laser pulses obtained from each of the 2 beamlines of the High Power Laser System (HPLS) of ELI-NP (Extreme Light Infrastructure – Nuclear Physics) research infrastructure. The laser system is a hybrid system made of a double CPA based on amplification within Titanium Sapphire crystals combined with an OPCPA with a parametric amplification stage boosting the energy to 10 mJ at the entrance of the second CPA. A XPW filter is also inserted between the 2 CPA and, in combination with the OPCPA, improves the temporal contrast of the pulses by typically 7 orders of magnitude. The spectral effects occurring during amplification, such as gain narrowing and wavelength shifting, are compensated through the use of spectral filters. Final amplification stages are involving large aperture TiSa crystals (up to 200 mm), which are pumped by high energy frequency-doubled Nd: Glass lasers delivering each 100 J of green light. Laser beams have been amplified respectively up to 332 J and to 342 J of pulse energy at 1 shot per minute without any occurrence of ASE and transverse lasing thanks to index matching fluid surrounding the crystal over is the entire length and pump deposition split over the time before each beam pass within the TiSa crystal. We have demonstrated full aperture compression by metric gratings of these amplified pulses down to 22.3 fs and therefore made the full demonstration for the first time ever of 10 PW capabilities from a laser system.

Biography:

Viacheslav Kholodnov is leading research scientist at V.A. Kotelnikov Institute of Radio Engineering and Electronics of Russian Academy of Sciences. He is also professor at the Moscow Institute of Physics and Technology (MIPT Technical University) and the Moscow Institute of Radio Engineering, Electronics and Automation - Russian Technological University. He received MS degree in theoretical nuclear physics from the Moscow Institute of Engineering Physics (TU) in 1967 and doctor of sciences degree in physics of semiconductors and dielectrics in 1990.  He is the author of more than 200 journal papers and has written three book chapters. He is author of several tutorials for students and PhD students. His current research interests include theory of optical and photoelectrical phenomena in semiconductor structures including multilayer structures with graded-gap layers and avalanche photodiodes.

Abstract:

Timing:09:55:00 to 10:20:00 EDT

Theory-based, it is shown that inhomogeneous illumination with specific profile shapes along electric field in semiconductor can even lead to abnormal photoelectric effects. Depending on profile shape of the density of photogeneration rate  of charge carriers, phenomena of self-amplification, self-quenching, and sign self-inversion can occur. In the latter case, under exposure of illumination, the current through semiconductor sample decreases (negative photoconductivity). The corresponding photogeneration profiles are calculated. Profiles are defined by parameters of semiconductor material, temperature of the sample and magnitude of electric field strength in the absence of illumination exposure.

The effects are due to a local photoexcited charge. Photoexcited local charge affects strength of photoexcited electric field. Such a charge affects the recombination-generation process. Therefore, photoelectric effects are caused by change in the population (which is nonequilibrium) of recombination level. A similar change of nonequilibrium population occurs with increase in concentration of recombination centers leading to a giant splash in lifetimes of mobile charge carriers and transit-time field-depended photoelectric gain. Neutral shape of illumination exposure profile has been calculated, i.e., when photogenerated charge exists although, but simple will be presented (as in the quasineutrality approximation) in distribution equation for concentration of nonequilibrium carriers. The results can be used to increase significantly in photoelectric response of semiconductors. For example, further increase in giant splash in photoconductivity of a semiconductor is possible with increase in concentration of recombination centers.

The results obtained fundamentally change modern ideas about the possible photoelectric effects in semiconductors and can be used to create a new generation of photodetectors of weak optical and short-wave radiation.

Biography:

Jingbo Qijoints University of Electronic Science and Technology of China (UESTC) as a Professor in the School of Electronic Science and Engineering. Prior to attending STC, he was a Professor at the PEAC Institute of Multiscale Sciences. Before that, he was a postdoctoral research associate in the Los Alamos National Laboratory and National High Magnetic Field Laboratory, respectively. He received his Ph. D. from Vanderbilt University. His primary research interests are in the field of ultrafast spectroscopy and THz spectroscopy of the condensed matter systems. Specifically, he is interested in the coherent control of quantum materials and ultrafast manipulation of light (electromagnetic wave) properties via quantum materials.

Abstract:

As a fascinating topological phase of matter, Weyl semimetals host chiral fermions with distinct chiralities and spin textures. Optical excitations involving those chiral fermions can induce exotic carrier responses, and in turn, lead to novel optical phenomena. Here, we discover strong coherent terahertz emission from Weyl semimetal TaAs, which is demonstrated as a unique broadband source of the chiral terahertz wave. The polarization control of the THz emission is achieved by tuning photoexcitation of ultrafast photocurrents via the photogalvanic effect. In the near-infrared regime, the photon-energy dependent non-thermal current due to the predominant circular photogalvanic effect can be attributed to the radical change of the band velocities when the chiral Weyl fermions are excited during selective optical transitions between the tilted anisotropic Weyl cones and the massive bulk bands. Our findings provide a design concept for creating chiral photon sources using quantum materials and open up new opportunities for developing ultrafast optoelectronics using Weyl physics.

Biography:

Xiaodong Zhang, a Professor, has completed his M.E. and a Ph.D. degree in Mechanics from Xi’an Jiaotong University, Xi’an, China. He has published more than 100 papers, includes 30 papers indexed by SCI & about 50 papers indexed by EI, and won 20 Patents of invention & 10 Design Patents. And He serves as an Associate Editor of the Journal of Mechanical Science and Technology & Editor of Intelligent Service Robotics.

Abstract:

In recent years, with the increasing popularity of wind power technology and the rapid development of wind power industry, the production of Direct-Driven Wind Turbines (DDWT)is increasing year by year in the world. The air gap between the stator and rotor is an important parameter to characterize its fault information, whose size generally ranges from 4 to 8 mm. In this paper, the measurement range of the current double-loop coaxial optic fiber displacement sensor is firstly analyzed, so that an approach for increasing the measurement range of the optic fiber sensor is proposed by increasing the number of receiving optic fiber circles. And then, the mathematical model of output modulation function is deduced when the sensor has a different number of receiving optical fibers, and the simulation results for the modulation function of the multi-loop receiving optical fibers sensor show that the measurement range of the dual-loop coaxial, optical fibers displacement sensor can be increased with 71.9% by comparing with the current one. Finally, in the calibration experiment of the sensor, the results of the actual measurement range are consistent with the theoretical simulation.

Biography:

Paulo P. Monteiro received the diploma “Licenciatura” in Electronics and Telecommunications Engineering from the University of Aveiro in 1988, an M.Sc. in Electronic Engineering, from the University of Wales UK, in 1990 and the Ph.D. in Electrical Engineering, from the University of Aveiro, in 1999. Presently, he is an Associate Professor at the University of Aveiro and Senior Researcher at the Instituto de Telecomunicações. His main research interests include Optical Communication Networks and Microwave Photonics. He tutored and co-tutored successfully more than 14 Ph.D.’s, having participated in more than 28 research projects (national and international). He has authored/co-authored more than 18 patent applications and over 110 papers in journals and 380 conference contributions. He is a member of the ECOC Technical Program Committee and Senior Member of IEEE.

Abstract:

Photonics is expected to revolutionize approaches for next-generation Radar and LiDAR systems since it can provide high spectral purity on signal generation and signal integrity on the detection and processing of high-frequency signals.

Photonics is also enabling the implementation of a distributed network of coherent multi static MIMO (Multiple Input-Multiple Output) radars with co-located or widely separated antennas exploiting spatially distributed information enhancing the detection capability in case of complex targets.

This talk discusses the main trends of using Photonics in Radar and LiDAR Systems and the approach followed in the projects RETIOT (Reflectometry Technologies to Enhance the Future Internet of Things and Cyber-Physical Systems) and LANDmaRk (Light communic AtioN Detection and Ranging).

Biography:

Will be updated soon 

Abstract:

To obtain nanostructures and thin films on a solid surface with controlled topology, we used several techniques. Namely, in addition to direct laser modification of solid target surfaces, the schemes with laser ablation of various targets (noble metals and their complexes with graphite and silicon, bimetals, refractory metals, semiconductors, graphite, etc.) in various liquids (from water to ethanol and glycerin, liquid nitrogen) with widely ranging viscosity were also implemented. In this case, first, a colloidal system was obtained; then, nanoparticles were deposited from the colloid on a solid surface to form the nanostructures of required topology in two ways: by laser radiation and by a drop method from the colloid through an appropriate nozzle. These processes in colloid systems with metal nanoparticles during laser ablation are associated with variations in local heating, an increase in the exposure time of each specific local volume, and control of laser-induced thermal diffusion of nanoparticles in the liquid. In general, for the case, both non-steady states random and non-ergodic processes in dynamic cluster systems under conditions of size quantization take place and result in new phase transitions. Moreover, laser-induced nanostructures and thin films with controllable topology vs. time may be presented as 4D-laser technology fabrication of new structures and materials. This is due to the reason that, e.g. thermodiffusion, gas-dynamic evaporation in pore-like structures with bubbles, ablation products, ballistic movement of the particles in liquid depend on the laser pulses duration. Thus, the interaction effects of solid targets with laser pulses of different duration for obtaining of various nanocluster structures can be viewed as the possibility of synthesizing the 4D-objects, when the result depends not only on the stationary topological/geometric parameters of the system but also on the dynamic interactions in the system leading to different final stable structures.

2. Using numerical methods, we have demonstrated the procedures for obtaining thin granular metal films with an arbitrary topology upon variation in the control parameters of the problem, as well as the possibility of predicting both their optical properties and electrical conductivity by computer simulation. The electrical conductivity and reflection, transmission, and absorption coefficients in the visible spectral range were calculated for various cases. For this, modern computer technologies were used in combination with original computer simulation algorithms. As a result, a good agreement with experimental data was obtained.

3. In the experiment with nanostructures in thin films on the surface of a substrate, we observed competition between two processes: first, an increase in electrical conductivity as a result of the opening of new channels in a spatially inhomogeneous conducting system and, second, an increase in resistivity due to an increase in the distance between conducting islands. Such electrical transport properties are determined by correlated quantum states leading to the tunnel and hopping electrical conductivities. They can be represented as a special type of topological electrophysical surface structures (both localized and delocalized) for the bound states of charge carriers. A sharp increase in electrical conductivity (by several orders of magnitude) was detected in our experiments due to a change in the topological features of the thin-film nanocluster system. We consider some physical principles for such processes in partially non-uniform complexes with different elemental compositions of thin multilayer cluster films on a solid surface when free charged particles propagate along the boundaries of conducting surfaces. A fundamentally new point of our study is the finding of trends in superconductivity based on fundamental effects in nanocluster structures with a specifically selected topology.

4. Granular thin films formed from spherical metal nanoparticles (e.g., of noble metals) deposited on both the dielectric substrate and the surface of individual other nanoobjects of significantly larger size, e.g., in the Au + Si combination, are of special significance for the optical characteristics. These structures with a controlled optical response can be used in the development of various sensors, electrochromic devices, supercapacitors, photoelectrochemical converters of solar energy, etc.

5. The results of this work make it possible to consider new physical principles for creating topological optoelectronic and photonic functional elements in a hybrid (optics + electrophysics) circuit using various spatial structures of an ensemble of nanoclusters in thin films on a solid substrate at room temperature, which, in fact, are incommensurable structures with laser-controlled symmetry. The aforementioned features of the fundamental effects in nanostructured thin-film solid-state systems make it possible to speak about the formation of a new line of research, i.e. topological photonics, which has undoubted applied promise, in particular, for femtosecond nanoelectronics.

Biography:

Prof. Yosef Ben Ezra, Dean of Engineering Faculty at Holon Institute of Technology, received his Ph.D. from Tel-Aviv University. During 2003-2005 Prof. Ben-Ezra was the principal researcher in the joint industry-academy project TRANSMOR focused on automatic detection and classification of power transients in WDM optical communication networks. In the period of years 2007-2009, Prof. Yosef Ben-Ezra was the principal researcher in a joint industry-academy project, DIAMOND, that developed high-spectral-efficient modulation techniques for modern optical communications. In the framework of the MAGNET project, Tera-Santa Prof. Ben-Ezra develops the novel method of OFDM based on Multiwavelets. He is currently working on the silicon photonic implementation of the Multiwavelet OFDM in the Peta-Cloud consortium. He has co-authored over 85 papers in international journals and conferences in fields of semiconductor physics and nonlinear effects and optical communication. He is the author 15 chapters in scientific books and of 12 patents.

Abstract:

 Quantum dot (QD) lasers and semiconductor optical amplifiers (QD-SOA) are characterized by the ultrafast carrier dynamics, low threshold bias current, temperature stability, large spectral bandwidth, low energy consumption, and compatibility with modern photonic technologies. They attracted interest as promising candidates for the applications in modern photonics due to these exceptional properties caused by the 3D confinement of the carriers in QDs. We investigated the influence of the carrier dynamics in QD lasers and QD-SOA on their performance as the photonic system components theoretically. We proposed the theoretical model of all-optical processors based on the Mach-Zehnder interferometer (MZI) with QD-SOAs in both its arms, which can perform under different conditions wavelength conversion (WC), logic operations, and optical regeneration. We investigated theoretically different applications of QD lasers and QD-SOAs for radio-over-fiber (RoF) for 5G systems,all-optical memory, and ultra-fast switching for the data centers.

Biography:

Will be Updated shortly

Abstract:

Timing: 11:10:00 to 11:35:00 EDT 

Some time ago we discovered that placing the Langmuir trajectories [1] of the type one i.e. those in the Hoop Earrings configuration in a combination of the symmetry augmented Circularly Polarized (C.P.) electromagnetic field and the magnetic field perpendicular to the planes of both electron parallel circular motions results in classical stabilization of there sulting Langmuir trajectories which therefore can support the stable non-dispersing quantum Trojan Wave Packets [2].

We have also considered several other configurations of electrons and fields leading to the existence of the stable, shape invariant Trojan or Trojan-like wave packets of one or two-electrons moving on circular or near-circular orbits. The common feature of those configurations is that the large angular momentum of the electrons is precisely adjusted to the Coulomb, Lorentz, and the electromagnetic field driving force, so each of the electron orbits stays circular and therefore frozen in the rotating frame.

Here we show that the Langmuir trajectories of type two i.e., those corresponding to the popular toy, the Click-Clack Balls when two electrons are moving in one plane on the semi-circular trajectories with the opposite angular velocity, they bounce from each other, reverse the velocities and continue bouncing again and again also support such packets. While the field-free two-electron trajectories are semi-circular for each electron, the properly tuned resonant Linearly Polarized (L.P.) electromagnetic field is acting on each electron on a semi-circle like it was a Trojan electron in the Hydrogen atom. In contrast, the L.P. field is the superposition of two counter-rotating C.P. fields, each component of the field alternately couples to the electron with the proper sign of the angular velocity.  To stabilize and confine the system further, the static magnetic field can be added in addition to the resonant L.P. field. In that case, to preserve the symmetry of the trajectories, the polarization plane of the L.P. must rotate with half of the cyclotron frequency corresponding to the magnetic field to balance otherwise asymmetric Lorentz forces acting differently of each of two electrons. Therefore in the former case, the trajectories and the corresponding wave packets moving along them exist in the frame rotating with the plane of the L.P. field polarization i.e., the electron bouncing point is rotating in the laboratory frame.

Unlike for the Trojan wave packets, the packets are not perfectly shape-invariant due to the reoccurring quantum collisions but still are highly confined and non-dispersing.

We use the generalized Gaussian ansatz

ψ=Nexp[−ΣM_ijx˜_ix˜_j],                                                                                               (1)

x˜_i=x_ix_0i(t) for the packet wave function and solve the equations for the localization matrix M(t) together with the classical equations of the motion.

We find the non-dispersing wave packets in the joined combination of the external L.P. field and the static magnetic field and the frequency tuned to the natural frequency of the closed periodic orbits drawing the single electron semi-circles. Numerical simulations using the split operator method for the 3D Hartreeap- proximation as well as our recently developed Time-Dependent Quantum Diffusion Monte Carlo Method are also provided.

Biography:

Bárbara Sampaio Dias Martins Mansano graduated as the best academic performance in Biomedicine at Paulista University (2010-2014) and qualified in Human Histology at São Paulo University (2014), performing sandwich graduation in Biomedical Sciences at Wright State University (2012-2013) by the Science Without Borders program (CAPES and CNPq). After, she obtained her master's degree with two honorable mentions in Biological Sciences (Molecular Biology) at the Federal University of São Paulo (2015-2017) with FAPESP scholarship. Also, she specialized in Teacher Education for Higher Education at Nove de Julho University (2017-2018). Currently, she is doing a Ph.D. in Biophotonics Applied to Health at Nove de Julho University with CAPES scholarship, participating in published studies, and a second-place prize work. Her research interests and experiences are in the fields of Molecular Biology, Biotechnology, Immunology, Biochemistry, Biophotonics, and Histology.

Abstract:

Timing: 15:30:00 to 15:45:00 EDT 

Myocardial infarction is a major cause of morbidity and mortality worldwide. Mesenchymal stem cells (MSCs) are being studied due to the paracrine effects of secreted cytokines and growth factors that decrease inflammation and scar formation and increase local capillarity in infarcted myocardium. However, the loss of MSCs at the transplanted site is large. To address this problem, the use of light sources is a promising tool. In this study, we irradiated MSCs with LEDs seeking positive changes in cell metabolism and enhancing cytokines and growth factors secretion to improve cardiac function later when transplanted into the infarcted heart. Adipocyte derived MSCs were obtained from Fischer-344 male rats (CEUA 5883160218), irradiated once every other day for a week with 630 nm LED box (Biolambda, Brazil) and analyzed the repercussion of different radiant exposures (0.5, 2 and 4 J/cm²). The Control group was kept in the dark for the same time as 4 J/cm²-placebo. Analyses were performed 24 hours after the last irradiation. None of the radiant exposures induced oxidative stress, DNA damage, or alterations in the levels of TNF-α. The 4 J/cm² irradiation up-regulated mitochondrial metabolism, ATP production, and IL-6, IGF-1, and NOx secretion. The 2 J/cm² had no significant action on the MSCs. Besides VEGF levels were significantly higher with 0.5 J/cm², a down-regulation in IL-10 level was detected. Thus, we concluded that the conditioning treatment with 4 J/cm² showed the best results in improving MSCs metabolism and secretion, being a good candidate to perform future cellular therapy in the infarcted myocardium.

Poster:

Biography:

Ayres Fernando Rodrigues is a Ph.D. student of the Postgraduation Program in Biophotonics Applied to Health Sciences, Nove de Julho University – UNINOVE, São Paulo, Brazil. Graduated in medicine in 1996, has a specialization in Orthopaedics and Traumatology surgery, both in from the Federal University of Mato Grosso do Sul, Brazil.

Abstract:

Timing: 16:30:00 to 16:45:00 EDT 

Bone lesions are increasingly frequent in brazil. Carbon materials, associated with silver nanoparticles, activated by photobiomodulation. They are promising in the treatment of infectious or aseptic bone failures.

The objective of this research is to evaluate the use of photobiomodulation associated with carbon material impregnated with nanosilver in the bone repair process in an experimental model of the bone lesion in the tibia of rats.

Wistar Rats (200-250g), 90 days of life, 120 animals will be used. The bone injury will be performed in the tibia, with a bone defect of 1.5 mm Ø x 0.5 mm deep (method proposed by Bossini)

Poster:

Biography:

Bianca Godoy-Miranda is graduated in Dentistry from Universidade Nove de Julho - UNINOVE. She was a monitor of the disciplines of Dental Materials ll and Periodontics I and ll, as well as an advisor to the League of Human Anatomy Milton Picosse Head and Neck and vice president of the Loducca League of Maxillofacial Surgery and Traumatology. She was also a member of the group of Scientific Initiation in Biophotonics from 2014 to 2017. She was a special student of the Master in Biophotonics and participated in the program "Paths for the Master". She is currently a specialist at UNINOVE in Public Health with an emphasis on Family Health and a student of the Master's degree in Biophotonics.

Abstract:

Timing: 15:00:00 to 15:15:00 EDT 

Periodontal disease is an inflammatory response to oral biofilm, and the treatment consists of scaling and root planing. As an adjunct to this treatment, antimicrobial photodynamic therapy (aPDT) has been used, and it consists of the use of photosensitizer (FS) and a light source for the formation of reactive oxygen species. Therefore, the study aimed to evaluate the use of aPDT in Aggregatibacter actinomycentecomitans, as well as the optimization of parameters. For this, A. actinomycentecomitans (ATCC 29523) was used, cultivated in microaerophilia for 48 h. Then, the experiments were carried out in triplicate, with 6 groups: 1) Control, without intervention 2) Light, which was only irradiated 3) FS, where only FS was used 4) PDT1, which was performed aPDT with irradiation of 1min 5 ) PDT3, PDT with 3 min irradiation and 6) PDT5, PDT with 5 min irradiation. Methylene blue (Sigma – Aldrich, USA) was used as a dye at the final concentration of 100 µM and irradiated with laser λ = 660nm (Photon Lase lll, DMC, São Carlos, Brazil) with a power of 100mW and a radiant exposure of 215 J / cm². After microbial growth, the cfu / mL count was performed, and the mean and standard deviation were performed. The control, light and FS groups showed 1x10⁹cfu / mL, and a microbial reduction of 7 orders of magnitude was achieved after 5 min of irradiation. It is concluded that aPDT was effective in microbial inactivation of A. actinomycentecomitans in vitro.

Poster:

Biography:

Claudio Teruo Kassa is a Graduate in Dentistry from the State University of Londrina - UEL in 1992. He is a specialist in Periodontics and Orofacial harmonization, qualified in Ozone Therapy, Laser Therapy, and Floral Therapy. Currently attending Post Graduation Program in Biophotonics applied to Health Sciences University Nove de Julho - UNINOVE.

Abstract:

Timing: 14:30:00 to 14:45:00 EDT 

Periodontitis is an inflammatory disease that affects the supportive tissues of the teeth in response to the presence of microorganisms. The gold standard treatment is scaling and root planing. To reduce the use of antibiotics, antimicrobial photodynamic therapy has been studied as an adjunct in periodontal treatment. The main limitation of the technique is the formation of dimers that decrease the effectiveness of the photosensitizer, and sodium dodecyl sulfate has been shown to decrease dimerization. The aim of this study is to evaluate the photodynamic effect mediated by methylene blue in sodium dodecyl sulfate for the adjuvant treatment of periodontitis. This clinical trial will be performed with 40 participants, and all of them will receive scaling and root planing. After 40 days, photodynamic therapy with real irradiation or placebo irradiation will be applied. The random allocation will be in the following groups: 1) group treated with scaling and root planing and photodynamic therapy with methylene blue in sodium dodecyl sulfate; or 2) with photodynamic therapy with methylene blue; 3) and the group treated with root scraping and straightening associated with photosensitizer without light irradiation and 4) treated with a photosensitizer in sodium dodecyl sulfate without light irradiation. The photosensitizer will be in contact for 1 min and the irradiation time or not 2 min. The laser’s wavelength will be 660 nm and 100 mW of power. The primary outcome will be microbial count, and secondary outcomes will be clinical probing depth, clinical attachment level, and bleeding on probing.

Poster:

Biography:

Daniella Teixeira Bezerra is a pediatric infectious disease specialist and joined, in 2019, the Nove de Julho University as a Ph.D. student in Biophotonics Applied to Health Sciences Program. She has been teaching medicine at the Nove de Julho University, since 2018. Daniella has knowledge of laser therapy, microbiology, and has experience in nosocomial infection control.

Abstract:

Timing: 15:45:00 to 16:00:00 EDT 

Infections are the leading cause of morbidity and mortality among patients with chronic kidney disease (CKD)on dialysis therapy. Staphylococcus aureus is a major agent, and previous nasal colonization represents an independent risk factor for infection. The nasal decolonization strategy reduces the infection rate in this population. The gold standard treatment is topical mupirocin, but there are reports of increasing bacterial resistance. Antimicrobial photodynamic therapy (aPDT) is a promising approach due to its potential bactericidal effect and low tendency to induce resistance.This controlled randomized, blinded, three-months follow-up clinical trial aims to compare the use of aPDT (»660nm, 400mW/cm², 0.01% methylene blue) with mupirocin therapy in nasal decolonization of among patients with CKD on dialysis therapy, through a semi-quantitative microbiological evaluation before and after intervention and recolonization time. Two groups G1- aPDT decolonization (n = 17) and G2- mupirocin treatment (n = 17) will be formed. Secretions from the anterior nasal cavities will be collected - at times T0 (before intervention- carrier status), T1 (first follow-up after intervention - decolonization effectiveness), T2, and T3 (at 1 and 3 months- recolonization). The samples will be sown in an anaerobic culture medium, and bacterial colonies will be identified by mass spectrometry - MALDI-TOF and tested for the antimicrobial sensitivity profile for Staphylococcus aureus(automated method Vitek 2). A questionnaire will be applied to identify possible factors related to colonization in this population. For statistical analysis: ANOVA two-way, complemented by the Bonferroni test. We expect treatments with aPDT and mupirocin to be equivalent.

Poster:

Biography:

Alexey Porfirev is a senior researcher in the Intelligent Video Data Analysis Laboratory of Image Processing Systems Institute of RAS—Branch of the FSRC “Crystallography and Photonics” RAS (Russia). He received his master’s degree from Samara National Research University (2010) and his Ph.D. in Optics from Samara National Research University (2013). Her primary research interests are in the field of diffractive optics, laser manipulation, and structured laser beam shaping.

Abstract:

Timing: 12:15:00 to 12:30:00 EDT 

The creation of the optical tweezer was one of the most significant events of the 20th century and provided scientists and researchers in various fields with a unique non-invasive method of three-dimensional trapping and guiding of nano- and micro-objects in a liquid medium or vacuum. In the last decade, active research has been conducted in the field of development of optical traps operating in air, allowing the manipulation and analysis of various aerosol airborne light-absorbing particles. An important feature of the manipulation of light-absorbing particles in the air is that with this method of trapping, the action of radiation pressure becomes almost imperceptible compared with the photophoretic forces resulting from momentum transfer between particles and surrounding gas molecules. It is well-known that the use of tightly focused Gaussian beams perfectly solves the problem of laser trapping and confinement of the nano- and micro-objects, both in liquid and gaseous media. However, the use of various so-called structured laser beams, which have become widespread in many areas of optics and photonics in recent decades, allows one to realize various types of manipulation with the trapped particles, including their rotation and three-dimensional guiding. Here, we investigate passive and active laser guiding of airborne light-absorbing particles using different structured laser beams – superpositions of optical vortex (OV) beams, circular Airy beams (CAiBs), and conventional two-dimensional Airy beams (AiBs). While superpositions of OV beams and CAiBscan be used for the generation of self-healing bottle beams, AiBsallow one to create curved light channels for passive guiding of the trapped particles along the accelerating trajectories. The unique properties of these beams, namely propagation along accelerating trajectories, self-healing, and auto-focusing properties allow one to use them for manipulation of airborne particles hidden behind obstacles. The experimental results demonstrate the possibility of a controlled three-dimensional movement of the agglomerations of carbon nanoparticles.

Acknowledgement : This work was financially supported by Russian ScienceFoundation (grant No. 19-72-00018).

Poster:

Biography:

Ellen Perim Rosa is a Ph.D. student in Biophotonics Applied to Health Sciences - Nove de Julho University. Specialist in Orthodontics, NAP Odonto, and DDS in Dentistry, UNINOVE. Interest in Biophotonics, Orthodontics, and Periodontics.

Abstract:

Timing: 16:45:00  to 17:00:00 EDT 

Corrective orthodontics is effective in recovering aesthetics and function; nonetheless, factors such as gingivitis contribute to its interruption. Orthodontic patients with gingivitis can be treated in the dental office with scraping; however, areas of gingival growth are difficult to access. Therefore, this study aims to test the effectiveness of antimicrobial photodynamic therapy (aPDT) as an adjunct in the decontamination of these areas. aPDT associates the use of a photosensitizer, light and oxygen  to promote an antimicrobial effect. In this clinical, randomized, and double-blind trial, 34 participants in orthodontic treatment, presenting gingivitis and gingival growth, will be included, divided into 1. Control group- Ultrasound scraping + aPDT placebo and 2. Experimental group- Ultrasound scraping + aPDT. aPDT parameters will be: methylene blue 0.005%, λ = 660nm, 9J per site, irradiance = 3.5W/cm, radiant exposure = 318J/cm2. The analyzes will take place at baseline, 7 and 21 days after treatment. Clinical parameters will include a gingival index, plaque index, and probing depth. The crevicular fluid will be collected from 4 sites for analysis of IL-6 and IL-10 cytokines, by ELISA. The test for parametric data will be one-way ANOVA and for non-parametric Mann Whitney. Data will be presented by means ± SD and p defined at 0.05. The results of this study may present therapeutic alternatives. It is expected that there will be a decrease in IL-6 and an increase in IL-10, as well as an improvement in the clinical parameters of sites treated with aPDT and scaling.

Poster:

Biography:

Gabriela Benedito is a Ph.D. student in Biophotonics applied to Health Sciences – UNINOVE. Specialization in University education UNINOVE; Master's degree in Biophotonics applied to health sciences (UNINOVE 2017-2019); Bachelor's degree in Chemistry (UNINOVE 2014-2016). Volunteer professor in the PIBID Project (2016), Volunteer Professor in the Mafalda Pre-vestibular course in Organic Chemistry (2015). She has experience in the following topics: Photobiomodulation - Mechanisms and Applications, Interaction of reactive species with biological systems: skin cell culture. Cutaneous photoaging, use of natural assets for photoaging. Experience in the methods: Cell Culture, Genica expression, lipid peroxidation, cell viability, among others.

Abstract:

Timing: 12:45:00 to 13:00:00 EDT

Skin photoaging is induced by ultraviolet radiation that leads to the formation of reactive oxygen species (EROS). Vegetal extracts present high antioxidant capacity due to polyphenols content. They act as reducing the concentration of the oxidizing species in the tissue and reducing inflammation, among others. Photobiomodulation (PBM) is a technique known by inducing cellular activity, ATP levels, modulating inflammation, etc. The combination of the antioxidant capacity of vegetal extracts and PBM seems to be a promising combination in order to reduce the harmful effects of UVA radiation. The objective of this work was to evaluate the catalase gene expression in human keratinocytes exposed to UVA after receiving vegetal extracts and PBM. For this, human keratinocytes (HaCaT) were seeded in 35mm well plates (150,000 cells/plate) and, after attachment was exposed to UVA (366 ± 10 nm, 2.5 mW / cm², 5400 sec). Then, treated with Chamomile (Chamomilla recutita Flower Extract) and Fig (Ficus carica Fruit Extract) extract at 0.3% for 24 hours and, finally, PBM (640 ± 12 nm, 2.6 mW/cm², 420 sec). At the end of the treatments, cells were kept in the incubator for 24 hours. RNA was extracted, and catalase gene expression was detected by quantitative PCR. In the dark, Chamomile increased catalase gene expression showing a photoprotective potential. UVA reduces the gene expression, while Chamomile use combined to PBM, showed an increased gene expression in relation to the UVA group. Fig extract does not alter the catalase gene expression in any treatment.

Poster:

Biography:

Jefferson André Pires is a physician, and general surgeon who graduated from the Federal University of Pelotas-RS, Brazil, graduating from the Ph.D. program in Biophotonics from the UNINOVE, São Paulo, Brazil and is also a resident in Plastic Surgery at the Conjunto Hospitalar do Mandaqui, São Paulo, Brazil.

Abstract:

Timing: 15:15:00 to 15:30:00 EDT 

Keloids are fibroproliferative scar difficult to treat and with high taxes of recurrence after treatments. The keloids etiopathogenesis is related to the disordered fibroblasts growth and an increase of the transforming growth factor-beta (TGF-β) levels. The main intervention is the surgical removal associated with the injection of corticosteroids. The photobiomodulation (PBM) with blue light has demonstrated in in vitro studies an inhibition of fibroblasts and TGF-β levels. The present study is a randomized, controlled, and double-blind clinical trial which aim is to verify the effects of PBM associated with the corticoid treatment during the pre and postoperative periods of keloid removal (keloids of any part of the body sutured primarily after the surgery). Participants (N=38) will be randomly allocated into two groups named: (1)Sham group (N=19) submitted to the standard procedure (corticoid + removal surgery) and (2) PBM group(N=19)  (PMB + Corticoid + removal surgery)using blue light (λ=470nm; P=400mW; E=24J, per point being 1 point per linear scar centimeter). The rate of recurrence and the quality of the new scars will be analyzed using the Vancouver scar scale. Silicone molds of keloids and new scars will be made and transposed in the acrylic surface to obtain measurements using optical coherence tomography. The histopathology of the resected keloid will also be analyzed to verify the fibroblasts, TGF-β, and collagen deposition and organization. Questionnaires (Qualifibro-UNIFESP and PSAQ) to assess the participant's quality of life and scar will be performed. The data will be submitted to statistical analysis.

Poster:

Biography:

José Marcelo is currently a Ph.D. student in Biophotonics Applied to Health Sciences, UNINOVE. He graduated in Nursing at UNINOVE, where he initiated his studies (scientific initiation) and got a master's degree. His primary objectives in research are related to photodynamic therapy applied in cell culture and/or microorganisms.

Abstract:

Timing: 13:15:00 to 13:30:00 EDT 

Methylene Blue (MB) is a compound that has been widely investigated as an antimicrobial agent for Photodynamic Therapy (PDT). Recently, our research group showed that the control of aggregation, through the association of MB with sodium dodecyl sulfate (SDS) potentiates the PDT action. However, in addition to optimizing the vehicle used, dosimetry also plays an important role in the outcome of therapy. The objective of this study is to compare the dosimetry of MB mediated PDT both in water and associated with SDS in Candida albicans. The fungi will be placed in two 48-well plates with their treatment (control; MB aqueous solution; SDS 0.25%; MB + SDS 0.25%). Then, the samples will be homogenized and incubated in the dark for 5 minutes. After incubation, one plate will be the plate that has been exposed to light (659 ± 9nm, in different dosimetry, i.e., keeping the irradiance constant and varying radiant exposure; later, doing the opposite). At the end of the irradiation, the samples will be diluted in ultra-pure water (10to 100000 times). The dilutions will be spread on sabouraud dextrose agar and placed in an incubator at 37°C for 24 hours. After this period, colonies will be counted. This work will show the most important dosimetric parameter (irradiance or radiant exposure) for antimicrobial PDT.

Poster:

Biography:

Marcelo Marreira is a nurse specialist in obstetric and gynecological nursing at the Abc School of Medicine. Master in Biophotonics Applied to Health Sciences by Nove de JulhoUniversity and Ph.D. student in the same department. He is a professor in the nursing department at Nove de Julho University.

Abstract:

Timing: 13:30:00 to 13:45:00 EDT 

The search for non-invasive aesthetic procedures for localized fat reduction has gained attention. Some studies have shown that Photobiomodulation (PBM) can be used in body contouring. However, there is no standardization of the protocol. The objective of this study will be to compare the different light wavelengths when using PBM as a technique for the reduction of abdominal waist circumference. 174 patients will be recruited, and then divided into 3 groups: RED PBM; INFRARED PBM; and PLACEBO (Sham). The treatments will consist of eight sessions, twice a week, for four weeks. At each session, the participants will receive 30 minutes PBM (127 J/cm²), and further, both groups will receive 30 min Aussie Current (4kHz, modulated at 10Hz, 40-60mA). The main outcome of this study will be waist circumference reduction. The secondary variables will be anthropometric data, lipid profile, liver function, changes in the local microcirculation, and the quality of life and self-esteem. The analyses will be performed at four stages of the research, D0, end of the eighth session, 15 days after the last session, and 180 days after the last session. This work will show the efficacy and the best wavelength for PBM when using for waist reduction. Since it will be expected that PBM release of triglycerides from adipocytes, Aussie current will act on the increase of b-oxidation. The control of the lipid profile is important since the availability of triacylglycerol may affect the lipid profile in the blood, bringing consequences for the general health of the individual.

Poster:

Biography:

Michelle M. Sena is a biomedical who joined as a Ph.D. student in the Postgraduate Program in Biophotonics Applied to Health Sciences at Universidade Nove de Julho (UNINOVE). Prior to attending UNINOVE, she was a master’s student in Experimental Pathology at the State University of Londrina and obtained a degree in Aesthetic Biomedicine postgraduate course. Her primary research interests are related to the use of photobiomodulation in the treatment of aesthetic dysfunctions, specifically in the determination of dosimetric parameters that can be applied in clinical practice.

Abstract:

Timing: 13:00:00 to 13:15:00 EDT 

The current routine that includes stress and sedentary lifestyle, alcohol consumption, smoking, poor eating habits, and low sleep quality, when combined with genetic factors, are directly related to overweight and fat deposits formation. This interferes with self-esteem and quality of life for a large part of the world population. Aesthetic resources destined for localized fat treatment, such as photobiomodulation and low-frequency ultrasound, although seem promising, have low scientific support for the combined use. This study will aim to compare the effects of photobiomodulation, low-frequency ultrasound, and the association of these techniques in abdominal localized fat. The main outcome will be abdominal skinfold thickness. Secondary outcomes will include anthropometric parameters, the temperature of the treated region, and biochemical and liver enzymatic markers will be evaluated. Visual changes due to treatments will also be assessed through photographic records. Finally, the subjective assessment will be collected through questionnaires that measure the quality of life (WHOQOL-BREF), the body self-image scale (BSQ-34), and the degree of patient satisfaction. The mechanism by which photobiomodulation acts in lipolysis is related to the production of reactive oxygen species that interact with the plasma membrane through lipid peroxidation, while low-frequency ultrasound seems to destabilize the membrane due to cavitation. Thus, both are involved on release of triglycerides present in adipocyte deposits for interstitial space, so it is expected that the combination of these techniques will lead to a greater reduction in the abdominal skinfold when compared to the isolated application of each technique.

Poster:

Biography:

Pamella Motta is a dental surgeon, a specialist in pediatric dentistry. She works in the field of facial aesthetics. She joined Nove de Julho University to pursue a master's degree in biophotonics. She developed an interest in the area because she already worked as an assistant to Ph.D. Sandra Kalil Bussadori, where she started using laser and led in treatments and developed an interest in research. Following the team's line of research, she conducts studies on halitosis. Pamella is also very interested in the use of laser in facial aesthetics. She really likes to travel and always tries to associate travel with studies.

Abstract:

Timing: 13:45:00 to 14:00:00 EDT 

Halitosis is a term that defines any foul odor emanating from the oral cavity. The origin may be local or systemic. The proposed project aims to determine whether treatment with antimicrobial photodynamic therapy (aPDT) and treatment with probiotics are effective at eliminating halitosis. 52 patients from 18 to 25 years old with a diagnosis of halitosis (H₂S ≥ 112 ppb determined by gas chromatography) will be randomly allocated to four groups (n=13) who will receive different treatments: Group 1 – treatment with teeth brushing, dental floss and tongue scraper; Group 2 – brushing, dental floss and aPDT; Group 3 – brushing, dental floss, and probiotics; Group 4 – brushing, flossing, aPDT, and probiotics. The results of the halimeter testing will be compared before, immediately after, seven days and thirty days after treatment. The microbiological analysis of the coated tongue will be performed at these same times. The quantitative analysis will be conducted using real-time PCRq. The normality of the data will be determined using the Shapiro-Wilk test. Data with normal distribution will be analyzed using analysis of variance (ANOVA). Non-parametric data will be analyzed using the Kruskal-Wallis test. The Wilcoxon test will be used to analyze the results of each treatment at the different evaluation periods. This study has been approved by the Ethics Committee of UNINOVE under process number 3.669.442. Results will be published in peer-reviewed journals and will be presented at national and international conferences.

Poster:

Biography:

Marcos Momolli is a doctoral student in the Biophotonics Department at Nove de Julho University (UNINOVE), São Paulo, Brazil. He is a general surgeon graduated at the Hospital de Clínicas de Porto Alegre (HCPA) and is attending the last year of his residency in plastic surgery at Conjunto Hospitalar do Mandaqui (CHM) in São Paulo. He is also a fellow student in Cosmiatry at the Boggio Institute in São Paulo. His main research interests are in the field of photobiomodulation for skin rejuvenation and tissue repair, which are important factors in his clinical practice.

Abstract:

Timing: 12:30:00 to 12:45:00 EDT 

Photodamage is a growing concern in contemporary society because it promotes early skin aging and different pathologies resulting from prolonged and repeated exposure to ultraviolet solar radiation, which is considered the main extrinsic factor of this process. Affected by radiation, the hands play an important role in the manifestation and visibility of aging, as they are very exposed body regions. Knowing this, a holistic body approach to rejuvenation is necessary, and hand treatment cannot be overlooked. This concern results in a growing rise in minimally invasive rejuvenation treatments capable of providing satisfactory results such as chemical peel and photobiomodulation. The study proposal is developed by the potential mechanism of tissue repair, skin rejuvenation, anti-inflammatory, and analgesic effects of photobiomodulation, complementing the benefits of chemical peel. Therefore, this randomized, controlled, double-blind clinical trial aims to compare the effects of monotherapy with 20% trichloroacetic acid (TCA) peel and the effects of the association of 20% TCA peel with 660nm LED photobiomodulation in photoaging treatment of hands. To achieve this, participants will be divided into two groups of different treatments and the results compared at the end of 04 sessions. Features of photoaging will be analyzed, such as fine and coarse wrinkles, abnormal pigmentation, and an overall assessment of the back of the hands through periodic standardized photographs. A visual analog pain scale and a 5-point Likert scale to assess participants’ satisfaction will also be applied at the end of the study.

Poster:

Biography:

Silvana Torres Perez is a Ph.D. student in the Biophotonics Applied to Health Sciences Postgraduate Program, Nove de Julho University - UNINOVE, São Paulo, Brazil, Graduated in Medicine, did Medical Residency in General Surgery and Specialization in Angiology and Vascular Surgery and has a master's degree in Biophotonics Applied to Health Sciences.

Abstract:

Timing:16:00:00 to 16:15:00 

Peripheral arterial occlusive disease (PAOD) is a late manifestation of atherosclerosis in the lower limbs due to a progressive decrease in blood supplying the tissues. Current treatments for PAOD are not so effective in the long term, and many patients progress to severe ischemia, running the risk of amputation. Photobiomodulation (PBM) has a proven effect on angiogenesis when using red and infrared sources. This project aims to evaluate the effect of PBM on angiogenesis (growth and proliferation of new blood vessels from existing vascular structures) and arteriogenesis (proliferation of pre-existing collateral arteries) using a lower limb ischemia model in rats. Visualization and measurement of the vessels will be performed via microscopy. 30 adult Wistar rats, under general anesthesia, will be submitted to thermography and oximetry of the hind legs, followed by surgical interruption of the femoral artery, causing ischemia. The animals will be divided into 2 groups (control and PBM). The control group will not receive any treatment. Irradiation with red (660 nm) and infrared (850 nm) laser, the total energy of 4 J / point every cm, will be applied 5x / week to the PBM group; the application will be along the femoral artery path, from the immediate postoperative period until the end of the experiment (30 days). Capillary density will be analyzed based on histological sections of the gastrocnemius muscle and measurement of collateral vessel density at 7, 14, and 30 days. The results will be treated statistically.

Poster:

Biography:

Thalita Molinos Campos is a dentist, graduated from Universidade Nove de Julho (UNINOVE). When she graduated, she won the João Sampaio Doria award, from the Regional Council of Dentistry, as the best student in the university's dentistry course. She did a residency in primary health care and family health, working with health promotion and prevention projects aimed at the population in social vulnerability. She attended a master's degree in Biophotonics Applied to Health Sciences also at UNINOVE, with works focused on photobiomodulation in oral mucositis and breast cleft. Today she is pursuing a doctorate within the same program. She is a collaborating professor in the dentistry course, within the disciplines of the health promotion nucleus, at the same university.

Abstract:

Timing: 14:15:00 to 14:30:00 EDT 

One of the most performed procedures in dentistry is the extraction of third molars, a surgery that causes a lot of discomfort to patients, with pain, edema, and trismus due to surgical trauma. To reduce these negative post-surgical effects, anti-inflammatory drugs are prescribed after extraction, but these drugs can have unwanted effects. Photobiomodulation is a technique to modulate inflammation, accelerate tissue repair, and also reduce pain and discomfort in different clinical situations, using low-level laser therapy and LED (light-emitting diode). Thus, the present study aims to carry out a Systematic Review of extraction in third molars with photobiomodulation, followed by a meta-analysis to assess cost-effectiveness. For the systematic review and meta-analysis, studies published between 2005 and 2020 will be selected. Searches will be conducted through the international databases PubMed, Web of Science, and MEDLINE. It will be used the search terms "third molar", "phototherapy"," dental extraction", "laser therapy", "third molar extraction", "photobiomodulation"," third mandibular molar", "third molar surgery", "low level laser therapy" and "wisdom tooth removal". The cost-effectiveness establishes whether or not a treatment should be implemented as a therapeutic measure, is calculated by the difference between the cost of two interventions proposed as treatment divided by the difference between its consequences (effectiveness). The costs will be based on the values with the treatment with the laser and with the use of anti-inflammatory, having as outcome measure pain (visual analog scale) and trismus (mouth opening-mm). 

This protocol is registered in PROSPERO CRD42018105658.

Poster:

Biography:

Maria Lucia Zarvos Varellis, Surgeon Dentist graduate from University of São Paulo, Specialist in Dentistry for Handicaps and Special Needs since 2002, PAHO consultant and Ministry of Health 2010-2011, Enable for use the Laser in Dentistry by SOBRALO and Federal Council of Dentistry, Enable for Hospitalar Dentistry by the Federal Council of Dentistry, Currently attending Post Graduation Program in Biophotonics applied to Health Sciences University Nove de Julho – UNINOVE. She is a professor and has been teaching Dentistry at the University Nove de Julho - UNINOVE since 2016, Line of research is in Photobiomodulation in salivary glands in patients with xerostomia induced by antihypertensive drugs, Participates in the training of undergraduate students for laboratory research.

Abstract:

Poster:

Biography:

Tainá Caroline dos Santos is a pharmacy and biochemistry graduate by the Universidade Nove de Julho (UNINOVE). She received her Master's Degree in Biophotonics Applied to the Health Sciences and Collective and Family Health specialization degree from Universidade Nove de Julho (UNINOVE). Currently, she is a Ph.D. student in Biophotonics Applied to the Health Sciences. Since her graduation, she was involved with the development of biochemistry educational tools. Her primary research interests are molecular biology and physiology. Specifically, she is interested in muscle injury and regeneration, inflammatory process, and photobiomodulation benefits. She is involved in studies with different experimental models.

Abstract:

Timing:14:00:00 to 14:15:00 EDT

Macrophages are key effector secreting products that can modulate the immune response during all phases of the inflammatory and tissue repair processes. Photobiomodulation therapy (PBM) with a low-level laser has been shown positive effects during the muscle repair process, modulating the cells involved in the inflammatory process, especially the macrophages. The aim of this study was to evaluate the effects of PBM on the synthesis of cytokines IL-6 and TNF-α in myoblasts cultivated in the presence of an M1 phenotype macrophage-conditioned medium previously submitted to the same irradiation parameters. J774 macrophages were activated with interferon-γ and lipopolysaccharide for 2h to induce the M1 phenotype. Irradiation was performed once using an AlGaAs diode laser (780 nm, 70 mW, 0.04 cm², 15 s, 1 J). C2C12 myoblasts were cultivated in a proliferation medium (DMEM + 10% FBS) and were irradiated with the same parameters used for the macrophages. After PBM, the myoblasts received 30% of M1 macrophage-conditioned medium (MCM1) from irradiated (+PBM) and non-irradiated macrophages. The IL-6 and TNF-α protein levels were detected 24 and 48h after C2C12 irradiation using ELISA kits. Untreated and PBM-treated myoblasts exhibited lower IL-6 levels in the presence of irradiated MCM1 at 24 and 48h. PBM treated myoblasts that received MCM1+PBM showed lower TNF-α levels after 24h in comparison to untreated myoblasts in non-irradiated MCM1. After 48h, untreated and PBM treated myoblasts exhibited lower TNF-α levels in the presence of MCM1+PBM. PBM performed concomitantly on myoblasts, and proinflammatory macrophages were able to modulate the synthesis of IL-6 and TNF-α protein levels.

Poster: