László Molnár
Institute of Biology, Faculty of Natural Sciences, University of Pécs, Hungary
Biological effects of electromagnetic waves: stimulation of cell proliferation and differentiation during regeneration as a unique property of THz impulses
Biography:
Dr. Molnár is a senior research fellow at Ecophysiological and Environmental Toxicological Research Group, Balaton Limnological Research Institute of Eötvös Loránd Research Network, Tihany, Hungary and an associate professor at the Department of Comparative Anatomy and Developmental Biology, Institute of Biology Faculty of Natural Sciences, University of Pécs, Hungary.
He is interested in the reparative regeneration of earthworms and its regulation with definite chemical and physical factors. He investigates the interaction of the immune and neural systems during regeneration and the effect of electromagnetic waves on tissue dedifferentiation and redifferentiation. He has been a PhD supervisor of the Doctoral School of Biology and Sportbiology and the Doctoral School of Physics (University of Pécs). In the London Interdisciplinary Doctoral Programme (King’s College, London, UK) he was a co-supervisor of a specific regeneration topic of a PhD dissertation (Brain regeneration, an earthworm phenomenon: from molecular characterization to bioengineering a functional “brain in a dish”).
Abstract :
Timing:16:30:00 to 17:00:00 Paris Time
There is a growing experimental evidence that all living things respond to electromagnetic waves. However, the published results, applying various experimental protocols and model animals, are controversial (both beneficial and disadvantageous effects of distinct electromagnetic irradiations have been reported).
The exploration of the biological effects of any electromagnetic irradiation needs both an exact, reproducible optical background and a standardisable biological model. One of them (posterior segments regeneration of earthworms) has been developed in our laboratory. The kinetic of the segment renewing (with its biochemical, cytological and histological backgrounds) has been elucidated under various physiological parameters. Therefore, its application in exact photobiological experiments can contribute to the recognition of the effects of defined electromagnetic irradiation on living things and supports the selection of relevant parameters for medical sciences.
Earlier we have shown that single-cycle THz pulses of 5 µJ energy, 0.30 THz mean frequency, 293 kV/cm peak electric field, and 1 kHz repetition rate has been overridden of the genetically determined, endogenously mediated segment renewing capacity of our model animal (Eisenia andrei, Annelida, Oligochaeta, Lumbricidae). In contrast to control specimens, a significantly higher number of renewing segments have been found in THz pulses exposed worms. The regenerated segments have had regular histological organization, no malformation has been seen in their tissues. In contrast, advanced tissue development has been recognized e.g. in body wall epithelium and muscles, circulatory system and immune cells and especially in the renewing ventral nerve cord ganglia. No similar effects have been seen in green, or red light exposed experimental animals, and the possible heating effect of THz pulses has also been experimentally excluded. In this presentation we show the ultrastructural and some histochemical characteristics (collagen deposition in cicatrix, dedifferentiation and redifferentiation of muscle cells, development of neurotransmitter specific cells, and iron distribution in old and new tissues) of distinct animal tissues exposed to defined THz pulses, suggesting their possible medical application.
Salam Nazhan
Diyala University, Iraq
Promising laser devices for optical communication, reliability, high-speeds and stability
Biography:
Salam Nazhan currently works at Diyala University as an Assistant Professor in the Department of Communication, college of engineering. He received the BS and MS degrees in physics, and electronics physics from Al Mustansiriya University, Baghdad, Iraq, in 1998 and 2005 respectively, and the PhD degree in optoelectronics from Northumbria University, Newcastle, United Kingdom in 2016. Prior to attending the Optical Communications Research Group at Northumbria University, he worked as a researcher with the optoelectronics group at Bangor University, Wales, UK, for around one year from 2011 to 2012. His research focuses on the characterization of lasers for free space optical communications, particularly, vertical-cavity surface emitting lasers (VCSELs) devices. He published many research papers in the top journals in the field and several conference papers. He also presented his research at a number of international conferences and events around the world
Abstract:
Timing:17:00:17:25:00 Paris Time (Presenter Local Time 18:00:00-18:25:00)
At the present time, optical communications (OC) either free space or fibers, are using laser beams as a carrier for transmission signals through communication channels. This field of study has become substantially interesting in research paper topics in the last few years. Therefore, investigation of OC based on laser beams gives attention greater than ever before in the research field.Free space optical communication (FSO) is concerned with data transmission through the atmosphere from one point to another using visible or invisible light to get a network connection.Optical sources or laser sources are utilized in such communication systems, it’s the key components to enable high-speed data transmission, reliability and stability of the OC system. Laser sources offer advantages in bandwidth and speed for FSO applications over the traditional systems of communications. Lately, the laser beam increases the wireless capacity of 5G services and beyond for future applications.Recently, underwater OC based on laser devices have also given wide interest in applications. Normally, FSO communication uses the wavelength range from short to long wavelength, which is from 700 nm to 1600 nm, because the wave optical energy which travels through the atmosphere has comparable properties at the visible and near-IR wavelength. However, shorter and longer wavelengths of laser beams are also being considered for specific applications. The wavelengths between 780-850 nm are the most popular and widely used due to readily available and inexpensive components, which has an attenuation of less than 0.2 dB/km.The semiconductor laser diode applications employ high pump sources, like edge emitting lasers (EELs), which are the dominant and traditional source. However, EELs are too costly, requiring optical fiber coupling, which results in additional power loss. Therefore, attention has focused on vertical cavity surface emitting lasers (VCSELs) devices with potentially low manufacturing cost for various applications including OC systems. VCSEL is a semiconductor laser, which has a resonant cavity that is vertically formed on the surfaces of the epitaxial layers. VCSELs gained a reputation as a superior technology for applications such as Gigabit Ethernet and intra-systems, FSO communications, optical fiber communications and optical recording.Furthermore, VCSEL with external optical feedback has become a hot security topic due to its encryption capabilities and is extremely popular in wide applications in modern communication. These brief words give a highlight to the topic and contribute to developing knowledge in a field of study.
Matt Kalinski
Utah State University, Logan , United States
Dynamic Ferroelectricity of Trojan Matter on Regular Lattices
Biography:
Matt Kalinski (born 1968) is US theoretical physicist who discovered Trojan wave packets, squeezed, coherent and intrinsically coordinate-entangled states of electrons in true atoms solving the long standing problem of interstellar rocket propulsion by extending the positron or positronium lifetime and control the arbitrary slowdown of the recombination process of antimatter in positronic rocket engine. Kalinski earned his PhD from the University of Rochester. The broad applications of his discovery of coherent non-dispersing electrons are important and not limited to photonic superconductivity, laser centrifugal isotope separation of Deuterium, detection of ultra-weak magnetic fields with Aharonov-Bohm effect and Berry’s phase, observation of Unruh-Davies effect as well as the detection of gravitoelectromagnetic force and precise engineering of complex quantum dot systems.
Abstract:
Timing:19:30:19:55:00 Paris Time (Presenter Local Time 11:30:00-11:55:00)
Some time ago we have discovered that the mutual interaction between the core electron in the Helium atom in a tiny so called elliptical state being the quantum analog of the elliptical Kepler orbit with the outer electron in the Trojan Wave Packet states is capable to maintain the dynamical polarization of the atom potentially eternally if small radiative friction effects are first neglected [1]. Such atom therefore as possessing a giant time dependent permanent dipole moment implements the dynamically ferroelectric Rutherford atom.
We discover that several types of regular two dimensional lattices like square, Honeycomb or face centered Honeycomb lattices are also capable to support stable ferroelectric or anti-ferroelectric ordering of rotating dipole moments by a strong short-range dipole interactions collectively generating a local Circularly Polarized electromagnetic fields self-consistently supporting Trojan or anti-Trojan Wave Packets.
Several parallel layers of such 2D lattices either with atoms perpendicularly aligned or symmetrically space shifted between the neighboring parallel layers like in case of the face centered (FCC) cubic lattice building the three dimensional lattices are also capable to maintain the ferroelectric or anti-ferroelectric order of all atoms coherently carrying circulating persistent currents in the Trojan Wave Packet or the anti-Trojan state.
We solve the system of the time-dependent Hartree equations within the nearest-neighbors Bethe-Peierls-Weiss approximation [2].
We obtain the following effective Gross-Pitaevskii-like equation for any lattice node.
where the summation is made over , either the nearest neighbors positions within a single lattice or nearest neighbors within the parallel lattices surrounding a given Trojan atom.
Kelly Cristina Quintela Martins Bitencourt
UniversidadeNove de Julho, Brazil
Photobiomodulation treatment modulates inflammatory mediators in DSS- induced colitis in mice
Biography:
Kelly Cristina Quintela Martins Bitencourt Master's student of the postgraduate program in Biophotonics applied to Health Sciences at Universidade Nove de Julho. Dentist surgeon and Nurse graduated from Universidade Nove de Julho, specialization in digital dentistry and qualification in laser therapy, specialization in periodontics, implantology, pediatric dentistry, public health, and intensive care. Experience in the hospital and outpatient area, and in public health, with activities developed in the intensive care unit, surgical center, ostomy units, cancer center, in hospital infection control, and hospital quality monitoring programs.Wide use of photodynamic therapy and photobiomodulation in dental treatments, such as endodontics, periodontics, peri-implantitis, and lesions of the oral cavity.
Abstract:
Timing: 17:45:00-18:00:00 Paris Time (Presenter Local Time: 12:45:00-13:00:00)
Colitis is debilitating illnesses characterized by severe inflammation of the gastrointestinal tract. Treatments currently available are expensive and palliative. We here investigated the role of Photobiomodulation (PBM) on dextran sodium sulfate (DSS)-induced colitis. Male C57BL6 wild-type (WT) mice were divided into four groups: Control, PBM, DSS and DSS+PBM. DSS was added to the drinking water of mice at days 0, 2, 4 and withdrawn at day 6. PBM treatment was performed daily for 90s from day 6 to 9 on the right and left sides of the ventral surface and beside the external anal region (Wavelength 660 nm, Potency 100 mW, Total Energy 15 J). Our studies evaluated the production of IL-1beta, TNF-alfa, IL-6, IL-10, IFN-gamma and TGF-beta in the bowel tissue. PBM treatment reduced IL-1 beta and IL-6 while increased INF-gamma and TGF-beta in the bowel tissue. Thus, PBM treatment modulates the bowel inflammatory response, constituting a potential tool for treat colitis.
Poster:
Gislene Freitas Franco
University of Sao Paulo, Brazil
Home-based photo biomodulation in the rehabilitation of patient swith chronic physical impairments. A systematic review.
Biography:
Gislene Freitas Franco Master's student in Biophotonics Applied to Health Sciences at Universidade Nove de Julho in progress (2021). Graduated in Nursing from Bandeirante University of São Paulo (2006), Post-Graduation at Faculdades Metropolitana's Unidas in U.T.I. adult (2017), Post-Graduation in Dermatology and Aesthetics from the Faculty of Technology of Valença (2019), member of the Brazilian Society of Dermatology Nursing. Courses extracurricular courses in Surgical Instrumentation, Facial and Body Aesthetics, Qualification in Lasertherapy (2019), Training in Wound Treatment with Therapy Photobiomodulation (2019), Wound Assessment and Treatment (2019), Update on Wound Care (2019), The importance of the Skin Specialist Nurse in the ICU (2019), I Journey of Stomatherapy. from Hospital Sírio Libanês (2019), Training in Epilation a Led (2020), participation and publication of an article in the Estetika Congress (2019) and at the 8th Brazilian Congress of Nursing in Dermatology (2020). Since 2016 inserted in the dermatological clinical context. Currently works at Instituto INA.
Abstract:
Timing: 18:00:00-18:15:00 Paris Time (Presenter Local Time: 13:00:00-13:15:00)
Sensorimotor impairments reflect the main sequelae of chronic and/or degenerative disorders that affect the neuromuscular and musculoskeletal systems and that require intervention and specialized care in ways to limit disability, functional rehabilitation, and improve the quality of life of the patients. Many muscular and/or neurovascular diseases, such as osteoarthritis and fibromyalgia, lymphedema, or neurological sequelae, could produce chronic impairment mental/or disabilities. As a result, during long-term follow-up, intra-hospital rehabilitation treatment can determine low adherence, high costs, and mobility difficulty. Domestic treatment could reduce costs, improve satisfactory results, and improve the qualityof life of the population. It isespecially important because COVID-19 highlights the urgency of using the home environment for continuity of healthcare. Inthis sense, thisstudyis a PRISMA systematic review todiscussif home-based photobiomodulation is a safe and effective technique in the treatment of patients with chronic physical impairments. We are interested in evaluating the changes in symptoms, functionality, and quality of life of patients with chronic impairments using home rehabilitation with photobiomodulation therapies. Our protocol was registered on the prosperous website before data extraction by No. CDR42022326588 and followed the Prisma guidelines. Clinical trials, case reports, guidelines, and observational studies evaluating the use of PBM in patients with chronic impairments of any etiology will be analyzed and available data about the quality of life, functionality, or degree of independence will be reported. The chosen tools for quality analysis of the included studies depend on the design of the data source. We intend to use the Cochrane risk-of-bias tool (RoB 2) for randomized trials; Cochrane Robins-I for non-randomized trials; and the CARE Tool for case reports. In addition, we will use the WALT recommendations to analyze the PBM parameters. If a minimum of two studies demonstrate population, stimulation parameters, and outcomes homogeneity, also intend to carry out a quantitative analysis of the extracted results (meta-analysis).
Ione Liz Paiotti
University Nove de Julho , Brazil
Effects of photobiomodulation on the prevention of the skin pressure injury in patients with a diagnosis of COVID-19: a randomized, controlled, and double blind clinical study protocol.
Biography:
Ione Liz Paiotti Graduated in Nursing and Obstetrics from de University of Taubaté (1981). Specialist in Hospital Administration at São Camilo, in Occupational Nursing by FUNDACENTRO, and Intensive Care at the University of Taubaté. I worked as a lecturer in a nursing technician course at Robert Wood Johnson Foundation School, in the chemical industry (Monsanto) as a Labor Nurse, and as a public servant in primary care. I implemented one of the first AMEs of the State of São Paulo, in the municipality of São José dos Campos. Worked in public and private hospitals as coordinator of Adult, Pediatric, and Neonatal ICU for 14 years. My greatest experience is in the area of hospital management. At the moment, I work as Director of Nursing in a public hospital, managed by SPDM (Paulista Association for the Development of Medicine), of university Nove de Julho and I am a master’s student in the Graduate Program in Biophotonics Applied to Health Science of the University Nove de Julho (UNINOVE), São Paulo, SP, Brazil.
Abstract:
Timing: 18:30:00-18:45:00 Paris Time (Presenter Local Time: 13:30:00-13:45:00)
The high incidence of pressure injuries (PI) is considered a serious public health problem and a negative indicator of the quality of nursing care. Objective: This study aims to verify the preventive effects of the use of photobiomodulation (FBM) in areas more susceptible to the development of PI in patients hospitalized with COVID-19. Methods: This is a controlled, randomized, and blind clinical study including hospitalized participants with a risk of developing PI according to the Braden scale. Participants will be randomized into 2 groups: Group 1 - Control (n=70) in which the hospital's standard operating procedures for the prevention of PI will be performed; and Group 2 - FBM (n=70) the same procedures as the group control and also FBM will be performed once a day, for 10 minutes in each of the 3 regions most commonly affected by PI, that is, sacral and calcaneal (bilaterally). The FBM will be performed using a plate with 132 LEDs of 660nm and 132 LEDs of 850nm(each LED has P=8 mW; E=4.89J, radiant exposure= 9.6 J/cm2; irradiance 16 mW /cm², 10 min). The incidence of PI will be evaluated every 48 hours after hospital admission for a period of 1 month or until hospital discharge if it occurs before this period. The time of onset of PI will also be evaluated, and the possible correlations of anthropometric data measurements and incidence of PI. The data will be statistically evaluated.
Poster:
Carolina Montovam Monteiro
Universidade Nove de Julho, Brazil
Nonionic and anionic polymers affect methylene blue aggregation in formulations for antimicrobial photodynamic therapy
Biography:
Carolina Montovam Monteiro is a Ph.D. student in Biophotonics applied to Health Sciences, has a Master's degree in Pharmacy (area of bioactive natural and synthetic products), a specialist in Homeopathic Pharmacy, graduated in Pharmacy and Biochemistry and Biological Sciences. She has experience as a compounding pharmacist for 21 years and as a professor in the pharmaceutical area for 12 years. She has been working as an undergraduate and graduate professor and author of books and teaching materials. She is currently a dative defender for the Ethics Committee of the Regional Council of Pharmacy of the State of São Paulo (CRF-SP) and a pharmaceutical consultant in compounding pharmacies, working mainly with legislation and regulatory matters, technical-administrative management, quality assurance, pharmacy technical development of cosmetics, homeopathic and allopathic medicines intended for topical, systemic and dental purposes, for human and veterinary use.
Abstract:
Timing: 18:45:00-19:00:00 Paris Time (Presenter Local Time: 13:45:00-14:00:00)
Methylene blue (MB) is a cationic phenothiazinium dye with interesting properties in antimicrobial photodynamic therapy (PDT). The aggregation state directs the mechanisms of action, which means that type I or II oxidative reactions can be favored according to the medium in which MB is conveyed (1,2). The purpose of this study is to develop MB formulations associated with polymers for aPDT, considering the optimization of rheological properties, and dimer-to-monomer ratio (D/M) and aims to bring improvements in clinical applicability. Methodology & Theoretical Orientation: Hydroxypropyl methylcellulose (HPMC) and Carboxymethyl cellulose (CMC) were used, respectively, as nonionic and anionic polymers, to reach a viscosity between 30 and 450 cP. The modulation of the MB aggregation state was evaluated in the presence or absence of the anionic surfactant sodium dodecyl sulfate (SDS). In triplicate, absorption spectra were recorded in a UV-Visible UV-1800 spectrophotometer (Shimadzu, Japan) from 250 to 800 nm using a 2 mm pathway cuvette. Absorption values determined the D/M at 614 nm (dimer) and 662 nm (monomer). The D/M values underwent a logarithmic transformation and were statistically analyzed using the one-way ANOVA test, followed by the Tukey post-test, adopting ?=0.05. Findings: There was a lower D/M ratio with an increasing concentration of polymers in the absence of SDS, however with the addition of surfactant, there was a D/M reduction in formulations containing both polymers studied, with lower MB aggregation being observed in the formulation containing the anionic polymer CMC when compared to the nonionic polymer HPMC. Conclusion & Significance: The addition of SDS to the medium in which the photosensitizer was conveyed and the ionic charge of the polymer, influenced the MB aggregation behavior. Further adjustments to this formulation will be necessary to control MB aggregation.
Poster:
Ana Carolina Alves Camargo Tortamano
Universidade Nove de Julho, Brazil
Comparative Study of Antimicrobial Photodynamic Therapy (aPDT) with and without Sodium Dodecyl Sulfate (SDS) for Aggregatibacter actinomycetemcomitans Biofilm Inactivation
Biography:
My name is Ana Carolina Alves Camargo Tortamano, I'm a dentist. I have a degree in Dentistry from Universidade Paulista (UNIP) in 2014, specialization in periodontics from Universidade Paulista (UNIP) in 2017, a master’s degree in Biophotonics applied to health sciences from Universidade Nove de Julho (UNINOVE) in 2019 and I am currently studying for a PhD in Biophotonics. applied to health sciences by the Universidade Nove de Julho. I am a professor of higher education at the Universidade Nove de Julho.
Abstract:
Timing: 19:15:00-19:30:00 Paris Time (Presenter Local Time: 14:15:00-14:30:00)
Aggregatibacter actinomycetemcomitans is a facultative anaerobic Gram-negative bacterium that is associated with periodontal disease. As an adjunct intervention to mechanical periodontal treatment, antimicrobial photodynamic therapy (aPDT) aims to produce reactive oxygen species to decrease microbial infection. It has been shown that sodium dodecyl sulfate (SDS) can improve aPDT results by increasing the formation of methylene blue (MB) monomers. The aim of this study is to compare the behavior of aPDT mediated by methylene blue in phosphate buffered solution (PBS) and with sodium dodecyl sulfate (SDS) in bacterial killing of A. actinomycetemcomitans. The biofilm will be grown on bovine dental samples and aPDT will be performed on them. Microbiological evaluation, scanning electron microscopy, and verification of the formation of reactive oxygen species will be carried out. For this, 2 groups will be created: PBS Group and SDS Group; and 6 subgroups: Control (not treated with laser or photosensitizer); FS (exposure to MB 100 mM photosensitizer for 1 min); Laser, irradiated for 5 min in the absence of FS; and three aPDT subgroups, with three exposure times of 1, 3 and 5 min of irradiation. A laser (Photon Lase III, DMC, São Carlos, Brazil) with a wavelength of 660 nm, output power of 0.1 W, well irradiation of 250 mW/cm2, energy of 6, 18 and 30 J will be used. corresponding to the time of 60, 180 and 300s and radiant exposure of 15, 45, 75 J/cm2. Subsequently, microaerophiles will be cultured, counted and converted into colony forming units per mL for analysis and comparison.
Poster:
Priscilla Farias Chagas
Estado university Rio de janeiro, Brazil
Analysis of the action of Photodynamic therapy in tissue repair of people affected by diabetic foot lesion
Biography:
Abstract:
Timing: 19:00:00-19:15:00 Paris Time (Presenter Local Time: 14:00-14:15)
Studies point to the positive response that photobiomodulation has in diabetic foot lesions. However, there is still a lack of cost analysis of this therapy, which has been growing more and more, but in the treatment of lesions. The aim of this study is to analyze the response of the action of photodynamic therapy in tissue repair of people affected by diabetic foot injuries and to identify the cost of this treatment. It will be a double blind, randomized study, patients will be divided into two groups, a control and an experiment. The research will be carried out in a Municipal Health Center (CMS) located in the west of the city of Rio de Janeiro, Brazil. As inclusion criteria, the following were listed: patients affected by neuropathic lesions of the diabetic foot, patients with good adherence to the therapeutic plan, assiduous patients in consultations, patients assisted by CAP 5.1. As an exclusion criterion, the following were listed: patients under 18 years of age; patients with wounds with etiologies that are not related to the diabetic foot, patients with ischemic diabetic foot who have an ankle-brachial index (ABI) with a value less than 0.9 or greater than 1.3. Patients with glycated hemoglobin greater than 8%. Data collection will be carried out through the medical records, in order to establish the sociodemographic and clinical profile of patients affected by diabetic foot injury and through the nursing consultation three times a week, where the patient will be submitted to the proposed treatment, being performed 10 sessions of photodynamic therapy. In all consultations, through a data collection instrument, such information will be collected to monitor the evolution of the lesions: lesion size, lesion characteristics (odor, type of exudate, type of tissue found in the wound bed, of the lesion, perilesional area and presence of biofilm and/or infection). The sample size will be 68 patients. This value was calculated to provide 95% power (α = 0.05). Initial descriptive analyzes will be performed considering all variables measured in the study, both quantitative (mean, median and standard deviation) and qualitative (frequency and percentage).
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Hamzah Adwan
Goethe University, Frankfurt, Germany
Laser-induced thermotherapy as minimally invasive treatment for hepatocellular carcinoma
Biography:
Hamzah Adwan is a medical doctor who graduated in 2021 from Goethe-University Frankfurt am Main, Germany, and is currently doing his residency in Radiology. He has been doing research since 2018 at the Department of Radiology at Goethe-University Frankfurt am Main in the field of Interventional Oncology under the supervision of Professor Thomas J. Vogl.
He has presented his work at a number of conferences and society meetings such as the CIRSE, IMSCB, ECR, Deutscher Röntgenkongress, and IROS. In addition, he has won a number of awards and recognitions including second prize winner of the oral presentation at the clinical sciences section at IMSCB 2020, and Scholarship holder of ‚Die hellsten Köpfe für die Radiologie‘ (brightest minds of Radiology) at Deutscher Röntgenkongress 2019&2020. He was selected as ambassador of IMSSB 2021. More recently, his abstract to the IROS 2022 in Salzburg/Austria was selected to be one of the ten best abstracts presented at the congress.
Abstract:
Timing: 17:25:00-17:45:00 Paris Time
Hepatocellular carcinoma (HCC) is the most common primary tumor of liver, and one the most common malignancies worldwide. There are many treatment options for HCC depending on the tumor stage such as liver transplantation, surgical resection, and locoregional treatments. These locoregional treatments are various and include Transarterial chemoembolization (TACE)as well as thermal ablation such as radiofrequency ablation (RFA), microwave ablation (MWA), and laser-induced thermotherapy (LITT).
LITT has unfortunately been less investigated compared to other thermoablative therapies. This makes the study unique, and interesting especially due to the many examined parameters.
The aim of this study was to retrospectively evaluate the MR-guided LITT in the treatment of HCC, according to treatment response, survival rates, and complications. This study enrolled 53 patients (12 women and 41 men; mean age: 67.5 ± 8 years) with 75 HCC lesions. All sessions were performed in analgosedation, and as an outpatient procedure. The included cases were investigated based size of tumors, ablation time, technical success, size of the post-ablation area, complete ablation, complications, local tumor progression (LTP), intrahepatic distant recurrence (IDR), overall survival (OS), and disease-free survival (DFS). Therapy response was assessed using contrast-enhanced MRI.
A total of 76 LITT sessions were performed. The mean preablation axial diameter of tumor was 2.4 ± 0.9 cm. Technical success was achieved in all sessions. The mean diameter of ablation area was 5.3± 1.8 cm. The mean ablation time was 16.7±7.4 min. Complete ablation was achieved in 98.7% (74/75) of the treated tumors. The rates of LTP and IDR were 3.8% and 64.2%, respectively. The 1-, 3-, and 5-year OS rates were 96.2%, 54.7%, and 30.2%, respectively. The 1-, 2-, and 3-year DFS rates were 54.7%, 30.2%, and 17%, respectively. There were no treatment-related deaths or major complications among the patients. The rate of minor complications was at 7.9% (6/76). LITT is safe and effective as local treatment for HCC, which can be performed in short time, and as an outpatient procedure without the requirement of general anesthesia. HCC patients treated by LITT, had a high OS time and low rate of LTP.