Biography:

Jose Maria Miguel Aguilera Cantero, MD, General Surgeon, Specialist in Phlebology, IMeLaS C Class Specialist by ISLMS, IALMS WFSLMS.

European Laser Association ELA Executive Board Member as Brother Latin Society. President of Paraguayan Association of Laser in Medicine, Surgery and Biophotonics. CorpsNatura Laser Medical Center- Asunción- Paraguay.

Abstract:

Timing: 12:25-12:50:00 Paris Time (Presenter Local Time: 07:25:00-07:50:00)

Chronic Venous Disease are spread around the worldwide, with no distinction through gender and middle age’s person. The Variety and type of presentation of lesions caused by CVD are very wide, such as complications of this stages of CVD correlated with others pathologies involved same patients. The Clinical Cases Study propose a transversal analysis of cases, during the years 2020 to 2022, since the Biophotonics Diagnosis method: ThermoPhlebology, correlated with Duplex Doppler Ultrasound, to stablish the CEAP Stage of the CVD, later we decide wich Laser Treatment it’s better for one by one case; Transdermal Laser vs. EVLA for each case of patients. The Follow Up of the patients was until 6 months of medical discharge data for the Laser Treatment. The CEAP STAGES (0 to 6) it still the worldwide nomenclature to describe the stage of the CVD for the UIP (Union Internationale de Phlebologié) for the Phlebology Medical Speciaty.

Biography:

Jacek Wojtas is an associate professor at the Institute of Optoelectronics, Military University of Technology in Warsaw, Poland. Member of the IEEE Photonic Society, the Optical Society and the Committee of Metrology and Scientific Equipment of the Polish Academy of Sciences. He has been managing Group of the Optical Signals Detection since 2015. Academic teacher and expert in optical signal detection, optoelectronic metrology and optoelectronic sensors for detecting traces of various volatile compounds. His research are focused on the use of state-of-the-art optoelectronic technology in gas sensors for environmental applications (gaseous pollution monitoring), medical diagnostics (detecting diseases biomarkers in human breath) and for safety systems (explosives detection). He has been awarded many times for his scientific and didactic achievements. The author or co-author of above 240 scientific publications, an associate or guest editor in 3 JCR journals and reviewer in over 20 journals and grant agencies.

Abstract:

Timing: 10:35:00-11:00:00 Paris Time 

Many effective methods for in-situ detection and concentration measurement of gaseous compounds have been developed so far. Nevertheless, laser absorption spectroscopy (LAS) plays a key role because it offers high sensitivity and selectivity as well as a quick response. Therefore, with the development of optoelectronic technology, LAS sensors are becoming more and more effective tools in the fight against environmental pollution and global warming, in order to control very expensive and complex technological processes in the industry, in order to support medical diagnosis and even detect and examine explosives. These sensors use the phenomenon of optical radiation absorption by the tested molecules. For this reason, they require a thorough matching of laser spectral parameters, the optical system and photodetector to the selected gas absorption band. The most commonly used spectral bands are the near infrared (NIR) and medium wavelength infrared (MWIR). This is related to the price and availability of components, as well as the location of the characteristic absorption bands of many gases with a high absorption coefficient (molecular fingerprints regions). However, the use of other optical bands may also have some advantages in gas detection. For example, sensors based on the absorption of long wavelength infrared (LWIR) radiation ensure a reduction in the negative effects of interferents such as water vapor and carbon dioxide, and in the side effects of Rayleigh and Mie scattering. Particular attention will be paid to Cavity Enhanced Absorption Laser Spectroscopy (CEAS).

CEAS sensors provide portability, non-invasive and high-resolution measurements in real time, fast detection of the lowest changes in the concentration, no need to replace sensitive components and calibration, self-control and safety of use. These advantages make these sensors very useful in many applications. Their principle of operation, functionality and performance will be discussed on some examples. Generally, the results of research carried out in the field of explosive detection will be presented, but some aspects of solutions for medical diagnostics will also be shown.

Biography:

Arpita Mishra joined the Indian Institute of Science as a Ph.D. Scholar in the Department of Electrical communication engineering. Before pursuing a Ph.D. She was a Project Staff at IISc. She received her M.Tech from IIIT, Bhubaneswar. Her primary research interests are in the field of Integrated Photonics based Sensors. In her free time, she practices yoga and explores the city for good vegetarian cuisine and instances of public art.

Abstract:

The horizon of near to mid-Infrared photonics expands after Germanium and Silicon Nitride materialization. Lately, these materials have attracted much interest because of their inherent properties, like a transparency window of 2-12 μm for germanium and 0.25-8 μm for silicon nitride, and its complementary metal-oxide-semiconductor (CMOS) compatibility. Concerning edge coupling, Grating couplers (GC) represent a desirable solution since they can be placed anywhere on the chip, allowing simple wafer-scale automated testing and providing much wider alignment tolerance. In this work, we have comparatively studied and designed a novel bilayer Grating Structure for germanium, and silicon nitride optimized using Finite difference Time Domain (FDTD) software. In this suggested structure, we have chosen a waveguide of height and width of 500 nm for Ge and 500 nm,600 nm for SiN for the confinement of mode required and optimized the grating by varying the tooth angle, etch depth, and period for each. We have also designed and optimized Bragg reflectors for each platform to maximize the coupling efficiency. The proposed novel trapezoidal bilayer grating structure on the GeOI platform couples 70 % of Transverse Electric (TE) and 60 % of Transverse Magnetic (TM) modes. The same design for SiN-OI results for 43% of TE and 53% of TM, respectively. The 3-dB Bandwidth of TE and TM for Ge-OI structure was 30nm and 40nm, while the same spectral response for SiN-OI was 210nm for TE and 150nm for TM. Thanks to the optimized design, these results represent the best performance reported in the literature for Ge-OI structures without using any back-reflector. SiN-OI and Ge-OI polarization independent grating coupler designed here can be widely used in optical communication, optical information processing, and optical sensing

Biography:

Krishna Kant Rana is a post-graduate student at the National Institute of Technology Warangal in the Department of Physics after completing his Bachelors of Science (B.Sc.) from St. Xavier’s College Ranchi. His primary research interests are the photonic integrated circuit for communication and sensing applications. In his free time, he reads novels of different genres and explores the city for diverse cuisine and instances of public art.

Abstract:

Group-IV photonics has gained a lot of interest in recent years due to its CMOS compatibility. Silicon on Insulator (S-OI) has dominated the optical and optoelectronics field for decades. On the other hand, the Germanium-based platform, Ge-OI, is another promising candidate for the abovementioned field. It has wide application in Mid Infrared Sensing due to its abundance, transparency, and high index contrast ( Δn = 2.6 at 3 μm) with reference to silicon on insulator. To take advantage of the wide transparency of Germanium in the Mid Infrared applications like chemical sensing, where most hazardous chemical molecules have their fingerprints, we have designed a compact adiabatic tapered waveguide sensor structure based on evanescent wave coupling, which will be able to sense more than six analytes (Carbon dioxide (CO2), Nitrous oxide (N2O), Nitrogen dioxide (NO2), Nitric oxide (NO), Ammonia (NH3), Ethylene(C2H4), Acetylene (C2H2), Hydrogen Cyanide (HCN), and Methane (CH4) has absorption peaks between 2.5 to 3.5 μm. The proposed device provides a suitable method for label-free detection of target molecules. It can be integrated on-chip for industrial and environmental monitoring, health analysis, and food processing which can be leveraged over hefty conventional spectrometers like Fourier Transform Infrared Spectroscopy (FTIR). In this work, we have done a comparative coupling analysis of taper structure with a standard slot waveguide. The improvement due to phase matching in the taper structure can be visible in the field available for sensing application. Single mode slot waveguide, while designed for a wideband of 1 μm, showed a feeble TM field for wavelength beyond 3 μm, while taper can support both TE and TM modes throughout the band. The slot waveguide is gap dependent for the TM mode, while the taper structure supports both modes for different gap values(50 μm,90 μm,140 μm,190 μm). We have also analyzed three different taper lengths (30 μm, 40 μm, and 50 μm) by varying etch depth and reported an optimum taper length of 40 μm for the proposed geometry, having transmission of more than 80 % for both fundamental Transverse Electric (TE) and Transverse Magnetic (TM) mode making it polarization insensitive.

Biography:

A visiting Research Scholar, at Key Laboratory for Physical Electronics and Devices of the Ministry of Education Xi’an Jiaotong University, China (Since 2015). After completing my Master from XJTU with three publications, I have been working with Professor Yanpeng Zhang. Since 2015, i have been visiting his lab to conduct the experiments for optimizing the control mechanism and coherence time of nonlinear rare-earth crystals. 

Since the last 5 years of actively working with Professor Zhang, I have published around fifty plus articles and peer-reviewed journals and few of them are with the corresponding authorship in the field of nonlinear and quantum optics. The most recent publication as a corresponding author is published in the New Journal of Physics [New J. Phys. 22 093008, (2020)].The pioneering work which i have developed with Prof. Zhang is the concept of hybrid entanglement for quantum hybrid communication [Sci. Rep. 1–8 (2016) and Sci. Rep. 1–12 (2017)]. With the concept of hybrid phenomenon,we have developed hybrid communication realization [Optics communications 127073 (2021)]. In this, we employed the dressed time energy entangled state using Cross-Kerr nonlinearity to produce a hybrid superposition of two states (coherent and incoherent).

Abstract:

Lithium is especially taken as a maintenance medication for bipolar disorder. In women with bipolar disorder, lithium is often effective during postpartum period, but breast-feeding for medicated mothers is controversial because of harmful effects for her child. At present, the biological mechanisms of lithium are not well-understood, affecting its usage and overall health implications.

We developed a rat lithium and breast-feeding model at human therapeutic levels to study the effects of lithium exposure through breast-milk on pups’ thyroid function and in kidney. Novel laser analytical spectroscopy with machine learning, traditional blood and immunohistochemical tests, were applied to further investigate the mechanisms behind the thyroid dysfunction. Maternal iodine supplementation was evaluated as a therapeutic method to address the pups’ thyroid dysfunction.

Pups exposed to lithium via breastmilk, even with the dam on a sub-therapeutic level, experienced weight gain, reduced blood thyroxine (T4), and elevated blood urea nitrogen, indicating effects on thyroid and kidney function. We show that lithium inhibited iodine uptake by thyroid follicles, initiating a mechanism that reduced iodination of tyrosine, thyroglobulin cleavage, and thyroid hormone production. Importantly, infant thyroid function can be significantly improved by administering supplementary iodine to the medicated dam's diet during breast-feeding. These results elucidate the mechanisms of lithium assisted by laser spectroscopy and machine learning.

Biography:

Ariane Cristina Zöll is a Physician Graduated in Medicine from FaculdadesIntegradas Padre Albino, previously Faculty of Medicine of Catanduva in 2011, with a medical specialization in General Surgery at Hospital Ipiranga in the City of São Paulo in 2015 and a subspecialization in Pediatric Surgery at Hospital Geral de Itapecerica da Serra in 2019, currently studying for a Ph.D. in Biophotonics Applied to Health Sciences at Universidade Nove de Julho inSão Paulo. She has experience in the area of Pre-Hospital Care as she worked in the SAMU 192emergency care service in the City of Osasco from 2012 to 2013 and from 2016 to 2018.

Abstract:

Timing: 12:50:00-1:05:00 Paris Time (Presenter Time: 07:50:00-08:05:00)

Cerebral palsy syndrome implies permanent movement and posture disorders in childhood. Its etiology is related to an insult or damage to the central nervous system during the prenatal, perinatal, or postnatal period when the central nervous system has not yet fully developed.  Approximately 80% of all individuals with cerebral palsy will be spastic, and this spasticity, untreated for a long time, generates anatomical and structural changes in bones, joints, muscles, tendons, and nerve junctions, with an impact on the quality of life, social participation, and physical function of this individual. Photobiomodulation therapy (PBM) has biological effects of tissue regeneration, reduction of the inflammatory process, and relief of pain symptoms, in addition to being feasible, safe, painless, and non-invasive. Objectives and methods: This study is a double-blinded, randomized, controlled clinical trial to evaluate the effect of photobiomodulation in reducing gastrocnemius muscle spasticity in 20 children aged between 2 and 18 years, diagnosed with lower limb spastic cerebral palsy from any etiology at least 03months, selected at the Rehabilitation Service of the Universidade Nove de Julho Campus VilaMaria and randomized at two groups: the application of Low-Level Laser Therapy in the medial and lateral right gastrocnemius muscles (device power of 100mW, the wavelength of 785nm, energy of 1J/cm(2)/point, applied in 04 points per muscle, during 40 seconds, three times a week for 12sessions ) or placebo Low-level Laser Therapy group (the same device turned off). Patients with fixed anatomic ankle deformity, malnutrition, severe gastroesophageal reflux disease, and other kinds of movement disorders will be excluded. Both groups will also receive the standard treatment for spasticity delivered by the rehabilitation health team of the hospital. To assess the response to therapy, the primary outcomes will be evaluated by the Modified Ashworth Scale, the FunctionalIndependence Measure (WeeFIM) for children, and the Visual Analogue Scale (VAS) for pain and passive and active ankle range of movement analyzed before and after the therapeutic session. The data will be statistically analyzed and the results reported and discussed. This study is in accordance with the research ethics guidelines of the University's Research Ethics Committee.

Poster:

Biography:

Ana Lucia Batista Aranha Master in Sciences from the University of São Paulo (2014). Doctoral Student at the Biophotonics Program at Nove de Julho University. Specialist in Nephrology from Unifesp (2009). Teaching at technical level by EAD-FIOCRUZ-USP (2010). Teaching in Higher Education - FALC (2013). Professor and Coordinator of the Nursing Course at the Faculty of Aldeia de Carapicuíba -FALC. (2012 - 2015). Has experience in Nursing, with emphasis on Nursing. Professor at Universidade Paulista - UNIP, Estácio de Sá, UNISA, Universidade Anhembi Morumbi. she is currently a professor at the Universidade Nove de Julho.

Abstract:

Timing: 18:45:00-19:00:00 Paris Time (Presenter Local Time: 13:45:00-14:00:00)

Fibromyalgia is a syndrome that occurs with complaints of chronic, generalized musculoskeletal pain associated with typical symptoms such as fatigue, sleep disorders, and cognitive disorders without known etiology, sometimes accompanied by headaches, paresthesias, and mood disorders, among other disabled complaints. Fibromyalgia is one of the most prevalent chronic diseases and causes of functional disability in the Brazilian public health system. Photobiomodulation therapy has often been used for pain management and is presented as a non-invasive, low-cost, safe therapy that has benefits in relation to the intensity of pain and the quality of life of patients. Besides, new systemic photobiomodulation techniques have been studied recently with the aim of promoting the effects of light on the immune system, pain, and systemic vascular, pulmonary, or musculoskeletal clinical conditions. Based on these premises, this study aims to investigate the clinical effects of the use of transcutaneous vascular systemic photobiomodulation (VPBM) in the treatment of patients with fibromyalgia. Methods: it will be a clinical, unicentric, randomized, controlled, blinded trial that will involve 44 patients with fibromyalgia in clinical follow-up at the Primary CareHealth School, Vila Maria from Universidade Nove de Julho (UNINOVE), Brazil. This study is in accordance with the research ethics guidelines of the University’s Research Ethics Committee. The patients will be randomly assigned to one of two groups: an intervention VPBM group(device power 100mW, wavelength 660nm applied transcutaneously at radial artery location during 100s, totaling 10 Joules in each session, 2X per week for four weeks) or a placebo VPBMgroup (the same device turned off, also twice per week for four weeks). Both groups will also receive the standard treatment for fibromyalgia delivered by the rehabilitation health team of the hospital. The outcomes of pain, quality of life, and functionality will be statistically analyzed by comparing the placebo and treatment groups in pre and post-therapy moments with the Visual Analogue Scale of Pain (VAS), the Brazilian Version of the SF 36 Quality of life scale, and the Brazilian version of the Fibromyalgia Impact Questionnaire (FIQ). The data will be statistically analyzed and the results reported and discussed.

Biography:

Abstract:

Timing: 11:15:00-11:30:00 Paris Time (Presenter Local Time: 06:15:00-06:30:00)

Endocarditis is an infection caused by an opportunistic bacterial that migrates to an injured endocardial. It affects 3-10/per 100,000 people every year, with a 30% of mortality rate. Staphylococcus is the most frequent and destructive microorganism that causes this disease. Usually, bacteria originated in an infection on another site, usually, the teeth, travel through the blood flow, and populate damaged areas of the myocardial, such as prosthetic valves, promoting vegetation, and tissue damage. This protocol aims to evaluate the usage of antimicrobial Photodynamic Therapy with transthoracic irradiation and Methylene Blue in the treatment of Infective Endocarditis in an animal model. In the induction of endocarditis, a catheter will be introduced in the carotid artery through surgery to produce a slight injury to the myocardium, and after two days the animals will be infected with Staphylococcus Aureus. An echocardiogram and hemogram will be used to confirm the infection, after which the Methylene Blue will be administered diluted in drinking water one hour before the irradiation procedure. The three study groups are as follows: 1: control infected group; 2: aPDT group with a single treatment and 3: aPDT group with 5 consecutive treatments (5 days). Each irradiation will be performed for 20 min with 800 mW LED emitting at 630 nm (342 J/cm2 at the surface of the rat’s thorax). Survival fraction as well as microbiological and imaging analysis will be performed in all groups. With this procedure, we expect to increase the survival rate of the subjects.

Biography:

Amanda Rafaelly Honório Mandetta Graduated in Dentistry from Universidade Nove de Julho - UNINOVE (2005). Specialist in Pediatric Dentistry by the Faculty of Dentistry of APCD-FAOA (2021). Master's student in Biophotonics Applied to Health Sciences at Universidade Nove de Julho - UNINOVE (Starting in 2022)Laser qualified by the International Academy of lasers in dentistry- IALD (2021)Calibrated in Incisor Molar Hypomineralization (MIH) by the Faculty of Dentistry of Araraquara-UNESP (2021)Clinical performance in private practice, in the city of São Paulo-SP, Brazil, in the area of pediatric dentistry, with care for babies, children, and adolescents, with emphasis on prevention and minimal intervention.

Abstract:

Time:13:05:00-13:20:00 Paris Time (Presenter Local Time: 08:05:00-08:20:00)

Molar incisor hypomineralization (MIH) is a qualitative developmental defect of enamel that occurs in the mineralization phase. MIH affects one or more permanent molars and occasionally permanent incisors. Patients with this condition have an increased risk of caries, hypersensitivity, and restoration failures. The aim of the proposed study is to evaluate the clinical effect of antimicrobial photodynamic therapy (PDT) on permanent teeth with MIH to promote decontamination and perform deproteination. Patients six to 12 years of age with permanent molars will be randomly allocated to three groups. The selected teeth must have a carious lesion in the dentin and post-eruptive enamel breakdown on one or more surfaces with an indication for clinical restorative treatment. Selective chemical-mechanical removal of carious tissue will be performed with Papacárie^TM (F&A) applied to the carious dentin and adjacent demarcated opacities to achieve deproteination. In Group 1, PDT will be performed with a low-level laser and 0.005% methylene blue as the photosensitizer with an irradiation time of three minutes. Group 2 will be submitted to selective removal of the carious tissue, PDT with low-level laser and 0.005% methylene blue as the photosensitizer with a pre-irradiation time of three minutes and deproteination with a 5% sodium hypochlorite solution. In Group 3, selective removal of the carious tissue will be performed with a dental curette. The teeth will subsequently be restored using a mixed technique with resin-modified glass ionomer cement and bulk-fill composite resin. All patients will be followed up after 48 hours and at three-month intervals for a period of 12 months. The effects of PDT will be evaluated in terms of decontamination (microbiological analysis) and post-treatment sensitivity (visual analog scale and Schiff Cold Air Sensitivity Scale). The effects of deproteination on the longevity of the restoration will be evaluated using the modified USPHS index. The data will be submitted to descriptive statistical analysis. Associations with age and sex will be tested using either the chi-squared test or Fisher’s exact test. Pearson’s correlation coefficients will be calculated to determine the strength of correlations between variables. Comparisons of the microbiological results (colony-forming units) will be performed using ANOVA and the Kruskal-Wallis test.

Poster:

Biography:

Thais Rodrigues Galache Graduated in Dentistry at Universidade Metodista de São Paulo (1998) and Biomedicine at Universidade Nove de Julho (2021). Master's student fellow in Biophotonics applied to Health Sciences (UNINOVE). Specialist in Orthodontics, Ozone Therapy and Orofacial Harmonization in Dentistry and Specialist in Aesthetics, Ozone Therapy in Biomedicine.

Abstract:

Timing: 18:30:00-18:45:00 Paris Time (Presenter Local Time: 13:30:00-13:45:00)

Statement of the Problem: Facial Melasma (FM) is a chronic pigmentation disorder difficult to solve. It affects women and their self-esteem. In vitro studies of photobiomodulation (PBM) with amber light showed inhibition of tyrosinase and reduction of melanin content. The aim of this study will be to evaluate the effect of PBM with amber light in the treatment of FM compared to tranexamic acid. Methodology: The study will be controlled, randomized and double-blind. The sample will be divided into 2 groups: One will receive amber LED and placebo topical cosmetics for home use; two will receive PBM sham and topical liposomal tranexamic acid for home use. Weekly sessions for 12 weeks and cosmetic use also for this period complete the protocol. Women aged 35 to 50 years, phototypes II to IV, and who have FM will be included. The use of any oral contraceptive, IUD, hormone replacement, autoimmune disease, use of photosensitive drugs, or receiving facial treatments in the 3 months prior to the study will be exclusion criteria. The severity of FM will be evaluated through Melasma Area and Severity Index, epidermis pigmentation will be evaluated by corneomelametry, photographic records and the quality of life questionnaire (MELASQoL-BP) will also be analyzed. Assessments will be made before the start of the study, at week six, and after the completion of treatment. Conclusion & Significance: This study may bring important information regarding the use of PBM in FM treatment. The study was approved by the ethics committee of Universidade Nove de Julho under no. 5,332,384 on April 5, 22. Clinical Trials no. NCT05326997 on 04/14/22. 

Poster:

Biography:

Roselene Lourenço has a medical degree in Clinical Medicine and Endocrinology, with extensive experience in clinical care, with a focus on the well-being and quality of life of her patients. She develops her activities in a General Hospital where she coordinates a Medical Clinic team and works in an outpatient clinic focused on the treatment of Diabetic Foot in a multidisciplinary group. In addition, she develops academic activities with undergraduate medical students and doctors in specialty training.

Abstract:

Timing: 13:20:00-13:35:00 Paris Time (Presenter Local Time: 08:20:00-08:35:00)

Diabetic foot syndrome is one of the most serious complications of diabetes mellitus and the main cause of non-traumatic lower-limb amputations. Preventive measures through multidisciplinary treatment collaborate in the preservation of limbs. Diabetic foot ulcer (DFU) is associated with loss of mobility, worse quality of life (QoL), and decreased overall productivity. The objective of this research is to evaluate the effect of photobiomodulation, as a preventive treatment of complications in patients with the diabetic foot without ulcers, when compared to the control group. Therefore, 54 patients with type 2 DM between 18 and 75 years old, with signs and symptoms of PN or claudication in the absence of UPD, will participate in this study.Participants will be randomized into two groups called G1 (self-care guidance + photobiomodulation) and G2 (self-care guidance + sham). The treatment will be performed using a boot-shaped LED device (robofoot) with light emission at wavelength 660 and 850 nm,durante 13 min,5 days a week for 12 weeks. The following outcomes will be evaluated: W6MT, TBI, thermography and mmii doppler before and after 90 days application of FBM, initial inflammatory and metabolic profile, 30 days and 60 days. Data collected during the research will be stored and organized in the Harvard Dataverse repository (https://dataverse.harvard.edu).And data analysis will be used Kruskal-Wallis test, followed by Student test. ComparisonbyWilcoxontest, significancelevelof 0.05

Poster:

Biography:

Marlon da Palma Cruz joined the Nove de Julho University as an undergraduate student in the Biomedicine course in 2012, and duly graduated in 2016, after his academic training he entered the field of research as a Master's student, in 2017, in the department of Biophotonics Applied to Health Sciences at Universidade Nove de Julho, presented works at international congresses (Nice/France) representing the department of Biophotonics, also won the third best work award at the IV International Forum on Laser therapy - FIL 2018. And today it is like a Ph.D. student at the Department of Biophotonics Applied to Health Sciences at Universidade Nove de Julho. His main research interests are lung pathologies and air pollutants.

Abstract:

Timing: 15:45:00-16:00:00 Paris Time (Presenter Local Time: 10:45:00-11:00:00)

Lung diseases constitute an important public health problem with high social and economic costs. Lung diseases are modulated by many factors including pollutants. Formaldehyde (FA) is a ubiquitous pollutant that induces inflammations and oxidative stress in the respiratory tract. Treatments currently available are expensive and with side effects. We here investigated the role of Photobiomodulation (PBM) in the lung inflammation induced by FA exposure. Male Wistar rats were submitted to FA exposure (1% or vehicle) for 3 consecutive days and treated or not with PBM (laser, potency 30 mW, 660 nm wavelength, energy density of 12.86 J/cm2) 1 and 5 h after each FA exposure. The rats were irradiated by 3 points in the trachea and 3 points in each lung lobe in order to promote irradiation of all respiratory systems. Twenty-four hours after the last FA exposure, we evaluated the generation of nitrites and hydrogen peroxide, as well as cyclooxygenases and nitric oxide enzymes. Our results showed decreased levels of oxidant enzymes and nitrites and hydrogen peroxide. Thus, PBM treatment modulates the oxidative stress in the lung tissue induced by FA.

Poster:

Biography:

Luir Ruaro Filho Graduated in Medicine from the State University of West Paraná (2003). He participated for four years in the scientific initiation. He completed his medical residency in gynecology and obstetrics in São Paulo (SP) at IpirangaHospital in 2010. In the same year, he began his master's degree in obstetrics at Hospital das Clínicas, Faculty of Medicine, University of São Paulo. Completion of the master's degree in 2013. He works as a preceptor in the medical residency of Gynecology and Obstetrics at IpirangaHospital since 2012. Professor at Nove de JulhoUniversityin the Medicine course and doctoral student of the postgraduate degree in biophotonics applied to health sciences at the same University. 

Abstract:

Timing: 13:35:00-13:50:00 Paris Time (Presenter Local Time: 08:35:00-08:50:00)

Lymphedema is a complication of breast cancer treatment characterized by swelling of the upper limb. Photobiomodulation (PBM) may be an option in the treatment of lymphedema after mastectomy for breast cancer. However, the level of evidence is uncertain due to the scarcity of studies designed with equivalent parameters. The objective of this study will be to evaluate whether PBM is able to reduce lymphedema, improve manual function and improve the quality of life of patients with lymphedema after mastectomy for breast cancer. This study will be double-blind, randomized, and controlled. Participants with lymphedema after mastectomy for breast cancer will be randomized into two groups. The treatment group will use the Institution's standard protocol for lymphedema (complete decongestive therapy) plus laser treatment at wavelength 850 nm, power 5 mW, and radiant exposure of 1.5 J/cm2. The control group will receive the Institution's standard protocol for lymphedema plus placebo laser treatment, all of both groups with 20minutes sessions twice a week and a duration of 12 sessions. It was estimated that 57 patients should be included per group in a total of 114 participants. Demographic data, quality of life, analog pain scale, limb perimetry, and manual function will be analyzed. Follow-up sessions will be performed at four and twelve weeks after the first therapeutic session. Descriptive analyzes will consider all variables: quantitative (mean and standard deviation) and qualitative (frequencies and percentages). All statistical tests will adopt the 5% significance level. The SAS for Windows program, version 9.1 will be used. The data will be statistically analyzed and the results reported and discussed.

Poster:

Biography:

Abstract:

Timing: 13:50:00-14:05:00 Paris Time (Presenter Local Time: 08:50:00-09:05:00)

The quality of sleep is directly linked to the quality of human life. Laser irradiation of blood in the transcutaneous vascular technique (ILIB) is believed to decrease blood viscosity and platelet aggregation; activate superoxide dismutase; promote increased oxygen content and stimulate microcirculation, it also stimulates increased serotonin production and cortisol reduction. Serotonin functions include sleep initiation, mood improvement, anxiety, and depression. Therefore, the objective of the present project is to evaluate the effect of ILIB on salivary biomarkers related to stress and sleep through a randomized, double-blind clinical trial, in which adults between 18 and 65 years old who complain of poor sleep quality will participate. Selected participants will be divided into 2 groups, group 1 undergoing ILIB Therapy twice a week for 30 minutes and group 2 the same frequency and time of application, but with placebo equipment. Upon patient admission, both groups will fill out questionnaires on sleep quality (PSQI and Epworth) and initial saliva will be collected for analysis of Chromogranin A (CgA) and Cortisol markers. The experimental group will receive the standard treatment procedures with active equipment and the second group will receive the technique through a placebo device. At the end of 10 sessions, the variables will be collected again. After the 30-day interval, a new saliva collection and application of the questionnaires will be performed for analysis of treatment response.

Biography:

Abstract:

Timing:14:45:00-15:00:00 Paris Time (Presenter Local Time: 09:45:00-10:00:00)

Osteonecrosis is a condition resulting from a partial or complete interruption in the supply of oxygen and/or nutrients to bone tissue, resulting in tissue necrosis. It can be caused by trauma, radiation, and also continued use of drugs such as the bisphosphonate class, corticosteroids, or drugs that act on bone remodeling and antiangiogenesis. The standard treatment for osteonecrosis is a conservative or extensive surgery, usually associated with antibiotic therapy. However, many patients do not improve symptoms. Therefore, other therapies are being studied, such as hyperbaric oxygen therapy and photobiomodulation showing favorable results. Thus, this PRISMA systematic review aims to evaluate the effect of photobiomodulation therapies on the treatment of medication or radiation-induced osteonecrosis, regardless location of necrosis. In this regard, prior to data extraction, our PRISMA protocol will be sent to properly register on the PROSPERO website, and it will include searches on PUBMED, EMBASE, LILACS, and Open Gray, Proquest, and LIVIVO databases using a P.I.C.O. strategy. Clinical trials, case reports, and observational studies evaluating the use of PBM in adult patients with radiation or medication-induced osteonecrosis will be analyzed. All available data about the quality of life and all outcomes analyzed by the authors of the included studies will be reported. Moreover, all photobiomodulation protocols used by authors will be included and reported. The chosen tools for the quality analysis of the included studies depend on the design of the data found. We intend to use the Cochrane risk-of-bias tool (RoB 2) for randomized trials; Cochrane Robins-I for non-randomized trials and the CARE Tool for case reports. In addition, we will use the LLLT/photomedicine Guideline published by Jenkins and Caroll and WALT recommendations to analyze the PBM parameters found. A qualitative descriptive analysis of the collected data is planned, but once the number of patients in published studies is in general limited, to come to a more accurate assertion if a minimum of two studies with the same material, same condition, therapy, and results are found, we plan to perform a quantitative synthesis (meta-analysis) of the subgroups of symptoms and quality of life outcomes.

Biography:

Abstract:

Timing:15:00:00-15:15:00 Paris Time (Presenter Local Time: 10:00:00-10:15:00)

It was predicted that there would be 670,000 new cancer cases worldwide in 2020–2022. It is known that the most common treatments instituted are chemotherapy, radiotherapy, and surgery. However, these treatments have undesirable side effects such as radiodermatitis (RD). In fact, it is estimated that the prevalence of possible side effects after radiotherapy is 80 to 90%. Radiotherapy complications are associated with a negative impact on the quality of life of patients. Few supportive care measures are available for such complications. In this way, the management of these side effects has been an object of study in the literature until today. In the other side, Photobiomodulation (PBM) has an important role in wound repair and tissue regeneration as it influences the different phases of lesion resolution, including the inflammatory phase, the proliferative phase, and the remodeling phase. In this way, the objective of this study is to evaluate the application of PBMT in the treatment of patients diagnosed with acute radiodermatitis induced by radiotherapy after breast cancer treatment. This is a case series report protocol in which the data will be derived from the medical records of all breast cancer patients with RD degree 2 or 3 treated at the Laser Therapy Outpatient Clinic in a university hospital followed from September 2022 until August 2023. The data collected comes from the patient's medical record. The outcomes are the size lesion, Visual AnalogicScale (VAS), and the Radiation Therapy Oncology Group Scale(RTOG) in the pre and post-FBM therapy moments. The data will be submitted to statistical analysis and will be discussed. Data with positive or negative results will be reported.

Biography:

Mayra Costanti Vilela CamposGraduated in Physiotherapy at Pontifical Catholic University of Minas Gerais (PUC-Minas) – in 2006. Specialist in nutrition, training, and exercise physiology from the State University of Campinas (Unicamp) – 2011. Graduated in Dentistry at Universidade Nove de Julho (UNINOVE) – 2022. Master's student fellow in Biophotonics applied to Health Sciences (UNINOVE).

Abstract:

Timing: 15:15:00-15:30:00 Paris Time (Presenter Local Time: 10:15:00-10:30:00)

Orofacial pain and tensional cephalea were symptoms commonly reported in COVID-19 patients, even after recovery, and were considered chronic pain in these cases. The pain control, in these cases, is mostly accomplished with the use of analgesic and anti-inflammatory drugs. However, there are auxiliary treatments that can reduce the amount of pharmacological intake and improve the quality of life of compromised individuals, one of them is photobiomodulation. Using lasers for treatments to control inflammation and pain is successfully performed, but the parameters and the ways of application are not yet strongly established. The aim of this research is to evaluate the effect of the application of photobiomodulation with red and infrared lasers applied locally and systemically. For this purpose, individuals who have been diagnosed with COVID-19 and have had a tension headache and/or orofacial pain for more than 3 months will be selected by convenience. The participants will be divided into two different groups: G1- photobiomodulation with red and infrared laser with local application on the pain points (808 nm and 660 nm,100 mW, 6J per point) and G2 -photobiomodulation with red laser with transcutaneous application on the radial artery (660 nm, 100mW, 30 minutes). All participants will be treated for a period of 4 weeks, with 8 application sessions. The effects will be measured by means of blood lactate level, Brief Pain Inventory, Visual Analog Scale (VAS), and Cephalea Impact Test. The data will be collected weekly before and after the treatment, and the following tests will be applied: Analysis of variance (ANOVA), Tukey paired T-test, Kruskal-Wallis, or Wilcoxon, according to data distribution. α= 0.05 will be considered as the level of statistical significance.

Poster:

Biography:

Abstract:

Timing: 16:00:00-16:15:00 Paris Time (Presenter Local Time: 11:00:00-11:15:00)

Randomized clinical trials conducted in recent years have shown that photobiomodulation modulates postoperative pain in endodontic instrumentation, especially in the first days after the procedure. Although the results are promising, there is still a low quality of evidence regarding the best dosimetric parameter to be applied. The aim of this double-blind randomized controlled clinical study will be to evaluate the effect of photobiomodulation(PBM) in reducing postoperative pain after the conventional endodontic treatment in maxillary molars. The sample will be composed of 58 participants endo dontically treated in a single session and randomly distributed in the PBM Group (n=29): conventional treatment + apical photobiomodulation (808 nm, 100mW power, 3J per point, 3mm2 area, 3 points - two vestibular and palatine, total energy of 9J) and Control Group (n=29): conventional treatment + simulation of photobiomodulation. As the primary outcome of the study, postoperative pain will be evaluated 24 hours after instrumentation, with a visual analog scale (VAS). The secondary outcomes will be:  pain, evaluated at 4h, 8h, and 12h after the procedure; pain on palpation (buccal and lingual) and pain on percussion (vertical and horizontal) which will be analyzed 24h after the procedure; the number of analgesics needed (paracetamol); and the impact of oral health on quality of life assessed by the OHIP 14 instrument. 

Poster:

Biography:

Abstract:

Timing: 16:15:00-16:30:00 Paris Time (Presenter Local Time: 11:15:00-11:30:00)

The bone graft added to the dental socket immediately after tooth extraction prevents atrophy and deformity of the bone at the site of element loss, allowing for further rehabilitation with implants. Photobiomodulation is a light-based approach that accelerates bone healing; stimulates blood flow; activates osteoblasts, decreases osteoclastic activity, and improves the integration of the biomaterial with bone tissue. The goal of this study is to develop a protocol for the management and preservation of alveolar bone after the loss of first and/or second permanent molars in pre-teen and teenage subjects between 8 and 17 years, with an indication for extraction. Materials and methods: 60 patients will be randomized and randomly divided into 4 groups, n= 15: Exo (extraction), Exo+Laser (extraction and laser treatment), Exo+Biomat (extraction with biomaterial), Exo+Biomat+Laser (biomaterial extraction and grafting and laser treatment). The biomaterials will be Geistlich Bio Oss Collagen ® and Geistlich Mucograft® (Switzerland), added to the socket immediately after molar extraction. Laser groups (λ = 808 nm, power = 100 mW, radiant energy 3J per point in 3 vestibular, occlusal, and lingual/palatal points), will receive irradiation immediately after the surgery, 48 h and 10 days after surgery, in the Exo and Exo+Biomat, will use a similar laser device without emission of irradiation. Analyzes: computed tomography and intraoral scanning performed preoperatively, 3 and 6 months after surgery; to assess bone volume by measuring the height and width of the socket in each group, trabecular bone, and the interdental space of the teeth lateral to the missing element. The clinical study received approval from the ethics committee and is in the recruitment phase.

Biography:

Abstract:

Timing: 16:30:00-16:45:00 Paris Time (Presenter Local Time: 11:30:00-11:45:00)

Incontinence-associated dermatitis (IAD) is an inflammation of the skin that occurs as a result of urine or feces contact in the perineal or perinatal region in adults. Lesions are typically located in the convex regions covered by diapers. The perineal region is the most affected, bringing pain and discomfort to the patient. The prevention and treatment of IAD must essentially follow two interventions: the control of incontinence/dampness and the implementation of a structured regimen of perineal care, seeking results for the restoration of skin integrity. Therefore, the gold standard for the treatment of IAD is skin hygiene, moisture control, and the use of a skin protector to restore skin integrity. Photobiomodulation has been used with excellent results in restoring skin integrity in acute and chronic wounds, but so far it has not been tested for IAD. To evaluate the effect of Photobiomodulation in the treatment of incontinence-associated dermatitis in adults.  A controlled, randomized, and blinded clinical study will be carried out on patients hospitalized in the Intensive Care sector, oncology, and coronary care unit of Honor Associação Beneficente Síria. Patients who developed lesions that present erythema with intact skin and erythema with loss of continuity, resulting from IAD, will be included in the study. Participants will be randomly divided into 2 groups: Control group (n=39) - use of liquid protective film in spray + FBM stimulation (placebo), Experimental group (n=39) - use of liquid protective film in spray + FBM. FBM will be performed with a 660 nm 100mW diode laser, 2 J per point, in 8 points and radiant exposure of 707 J/cm2. FBM will be applied once a day every 24 hours for 3 days in a row. Both groups will continue with daily skin care and diaper changes every 3 hours. The primary endpoint was chosen for the 7-day IAD lesion cure rate study. A photographic record of the lesion area and measurements will be performed using a disposable ruler with the patient in a lithotomy position on the days of the evaluations. For the classification and characterization of the severity of IAD, the Ghent Global IAD Categorization tool will be applied. In addition, the size of the area will be analyzed using the ImageJ software program. For pain assessment, the visual analog scale will be used in conscious patients and the BPS scale in patients with cognitive impairment and who are intubated. In adults with cognitive impairment, periods of confusion, and dementia, the Pain Assessment in Advanced Dementia- PAINAD scale will be used, with pain intensity from 0 to 10. All outcomes will be evaluated at baseline, at 24 hours, 3 days, and 7 days.

Poster:

Biography:

Ana carolina Barros Graduated in Dentistry at Universidade Estadual Paulista (UNESP) - 2012.Specialist in Orthodontics and Facial OrthopedicsatFaculdade São Leopoldo Mandic (2016). Master's student fellow in Biophotonics applied to Health Sciences (UNINOVE). 

Abstract:

Timing: 17:00:00-17:15:00 Paris Time (Presenter Local Time: 12:00:00-12:15:00)

Saliva is directly related to oral health and homeostasis, and therefore, the occurrence of caries, periodontitis, and fungal and bacterial infections can affect and compromise the population's quality of life. Changes in salivary parameters, such as decreased flow, and changes in pH and composition, can lead to changes in oral health, and prevention and treatment strategies need to be studied and developed. Studies using photobiomodulation have shown promise in the improvement of some salivary parameters. The aim of this study is to compare the effect of photobiomodulation with infrared laser protocols and modified ILIB therapy on the salivary parameters of adults affected by drug xerostomia. The sample will be composed of 30 adults, with healthy teeth, between 18 and 45 years of age, who will be divided into 2 groups, with 15 participants in each group. Each group will receive a type of light. Saliva will be collected, the volume will be measured and the salivary flow determined (ml/min). Salivary IgA concentrations will be measured in all samples. Infrared laser and modified ILIB will be applied to the determined group. Total saliva at rest will be collected before, immediately, 30 minutes, and 7 days after the interventions. The applications of the lights will be in the regions of the parotid glands bilaterally, as well as in the region of the submandibular and sublingual glands for the infrared laser and in the wrist for irradiation of the radial artery for the modified ILIB group. Data will be analyzed using Analysis of Variance (ANOVA) and Pearson's correlation test (=0,05). The Statistical Package for the Social Sciences (SPSS) (IBM Corp. launched in 2012. IBM SPSSStatistics for Windows, version 21.0. Armonk, NY: IBM Corp) version 15.0 will be used for all analysis.

Poster:

Biography:

Bárbara Evelyn Santos de Lima, graduated in Nursing at NovedeJulhoUniversityin2021,has received a fellowship to develop a research project on the effects of photodynamic therapy mediated by 5-ALA on cancer stem cells derived from oral squamous cell carcinoma. Actually, is studying for a Master’s degree in Biophotonics Applied to Health Sciences.

Abstract:

Timing: 17:15:00-17:30:00 Paris Time (Presenter Local Time: 12:15:00-12:30:00)

Oral squamous cell carcinoma(OSCC)is an aggressive neoplasm with high rates of relapse. Photodynamic therapy (PDT) is a promising therapy for the treatment of oral tumors in the early stages, however, its effectiveness is limited in the absence of T and NK (Natural Killer) cells. Thus, the objective of this study was to evaluate in vitro the cytotoxicity of NK cells after PDT.Methodology: The OSCC cell line CA1 was incubated with 5-ALA (1 mM) and exposed to different radiant exposure to determine the sublethal dose of PDT to be used in the cytotoxicity assay. Thus, cells were divided into the following groups: Control,5-ALA, LED, and PDT. Cellular viability was evaluated by the MTS assay. After 12h and 24h of treatment, cells from all groups were submitted to the Calcein-AM release assay using the NK92-MI cell line as effector cells in different concentrations. Findings: Ca1 cell line viability was reduced in all radiant exposures evaluated and the sub-lethal dose of PDT was observed with 3J/cm². After 12h and 24h of  PDT, no difference in regards to NK92-MI cytotoxicity was noticed in all groups evaluated. Conclusion & significance: PDT was able to decrease OSCC cellular viability at different radiant exposures. However, it seems that PDT was not able to increase the cytotoxic potential of NK92-MI cells against OSCC. Further studies considering 3D models and the tumor microenvironment are needed to better understand the effects of PDT on NK92-MI cells.

Biography:

Abstract:

Timing: 17:30:00-17:45:00 Paris Time (Presenter Local Time: 12:30:00-12:45:00)

Depression is the most common mental illness and antidepressants are the first line of treatment for depressed patients. This therapeutic class is inevitably associated with side effects and adverse reactions, xerostomia being a symptom that seems to be transverse to them all. Saliva performs multiple functions and plays a vital role in protecting the health of the soft and hard tissues of the oral cavity. Reductions in salivary flow are most often manifested as dry mouth, and this is the subjective complaint called xerostomia. Although xerostomia is the most frequent indication of reduced salivary production, it is not invariably associated with hyposalivation. The user of antidepressant drugs has a number of important systemic and oral complications. Treatment for salivary changes remains unknown, but low-level laser therapy has been shown to be effective in improving salivary flow in patients with xerostomia due to diabetes, Sjogren's syndrome, chemotherapy, and radiotherapy for head, neck, and lung cancer. This randomized controlled trial aims to evaluate oral symptoms related to salivary gland function and mucosal condition of depressed patients, as well as the effects of photobiomodulation on salivary flow. Sixty patients will be included in the protocol, after signing the Informed Consent Form. They will undergo anamnesis, physical evaluation, and oral health self-perception questionnaires and symptoms related to salivary gland function and then will be divided into two groups: Photobiomodulation (PBM)  (n=30); will have their larger salivary glands irradiated with Diode laser (808nm, 4J per point, the 40s) and placebo (PCB)  (n=30), which will be subjected to a simulation, where the application protocol will be repeated, but with the laser off. Previous and post-treatment sialometry will be performed to compare saliva volume. Biochemical analysis, in which total protein and calcium will be measured, will also be performed.

Poster:

Biography:

Pamella Motta is a dental surgeon, master in biophotonics from Uninove, a specialist in pediatric dentistry, and works in the area of facial aesthetics, joined the doctorate in biophotonics in 2021 at Universidade Nove de Julho. She became interested in the area because she previously worked as an assistant to Dr. Sandra Kalil Bussadori, where she started using lasers and led treatments and developed an interest in research. Following the team's line of research, she develops studies on halitosis. Pamella is also very interested in the use of lasers in facial aesthetics. She loves to travel and always tries to associate travel with studies.

Abstract:

Timing: 17:45:00-18:00:00 Paris Time (Presenter Local Time: 12:45:00-13:00:00)

Halitosis is a term that defines any foul odor emanating from the oral cavity. The origin may be local or systemic. The aim of this study is to determine whether treatment with antimicrobial photodynamic therapy (PDT) and treatment with probiotics are effective at eliminating halitosis. Fifty-two patients from 18 to 25 years old with a diagnosis of halitosis (H2S≥112 ppb determined by gas chromatography) were randomly allocated to four groups (n=13) who received different treatments: Group 1 – treatment with teeth brushing, dental floss, and tongue scraper; Group 2 – brushing, dental floss, and aPDT; Group 3 – brushing, dental floss, and probiotics; Group 4 – brushing, flossing, iPad and probiotics. The results of the altimeter testing were compared before, immediately after, seven days, and thirty days after treatment. The microbiological analysis of the coated tongue will be performed at these same times. The inter-group analysis was performed for each time studied individually. At the initial time, there was no significant difference between the studied groups (p = 0.0706, Kruskal-Wallis ANOVA), indicating that the groups were well balanced in relation to the initial condition. In the analysis of the other times after the treatments, no significant difference was observed between the groups studied (p = 0.9581, p = 0.6187 and p = 0.9635 for the times “immediately”, “7 days” and “30 days”, respectively. Kruskal -Wallis ANOVA). The analysis of the “Scraper” group showed that the time “immediately after” differs significantly from all other times (p = 0.0006, Friedman). The analysis of the “a PDT” group showed that the time “immediately after” differs significantly from all other times (p = 0.0008, Friedman). The analysis of the “Probiotic” group showed no significant difference in the times studied (p = 0.7530, Friedman). The analysis of the “PDT + Probiotic” group showed that the time “immediately after” differs significantly from the time “30 days” (p = 0.0008, Friedman). The objective of the microbiological evaluation will be to determine the effectiveness of hygiene control, a PDT, and probiotics for the reduction of bacteria on the surface of the tongue.

Biography:

Veronica Ovidio Carvalho de Santana graduated in Biological Sciences at Universidade Nove de Julho (2018), a Postgraduate in Teaching in Biotechnology atUniversidadeFranciscana (2022). Currently, she is a Master’s Degree student in Biophotonics Applied to the Health Sciences.

Abstract:

Poster:

Biography:

Fabiana Divina Magalhães, Is a dentist. she had a degree in from Universidade Federal de Uberlândia (UFU) in 2006, specialization in endodontics from Universidade Maringá (Uningá) in 2011,  master’s degree in Dental Sciences from Universidade Ibirapuera (UNIB) in 2021 and currently studying for a PhD in Biophotonics applied to health sciences by the Universidade Nove de Julho.

Abstract:

Timing: 18:15:00-18:30:00 Paris Time (Presenter Local Time: 13:15:00-13:30:00)

Endodontic infection is defined as the invasion and multiplication of microorganisms in the dental pulp, being responsible for pulp and periapical pathologies that occur when there is microbial persistence in the root canal system. Among the currently known endodontic retreatment methods, manual and mechanized retreatment, associated or not, and the use of solvents and intracanal medications can be mentioned. As these techniques are similar, the level of failure in retreatment ends up being high. In this sense, antimicrobial photodynamic therapy (a PDT) serves as an adjuvant in endodontic retreatment. It is a non-invasive technique that uses a photosensitizer and a light source for the formation of reactive oxygen species that cause bacterial death. However, the main limitation of the technique is the formation of dimers that reduce the effectiveness of the therapy. On the other hand, sodium dodecyl sulfate (SDS) showed the ability to reduce this dimerization effect. Therefore, the objective of this study will be to evaluate the photodynamic effect of methylene blue delivered in SDS at 0.25% for the treatment of patients with chronic periapical periodontitis in order to eradicate persistent microorganisms in previously filled root canals. The methodology will cover a sample of 30 patients with unsatisfactory endodontic treatment with chronic periapical periodontitis. These patients will initially undergo mechanized endodontic retreatment. After that, they will undergo treatment with photodynamic therapy. Patients will be randomized and divided into 03 groups, as follows: 1) mechanized endodontic retreatment (REM) and aPDT with methylene blue (n=10); 2) REM and aPDT with methylene blue in 0.25% SDS (n=10) and 3) REM with placebo irradiation (n=10). Microbiological results will be evaluated by microbial counts before and after treatment and clinical findings by the absence of symptoms and radiographic parameters. Data will be treated statistically for comparison between groups. As a primary outcome, a reduction in intracanal microbial load is expected.

Poster:

Biography:

Dr. Rebeca Tudor has B. Sc and M. Sc degrees in engineering, from the Faculty of Electronics, Telecommunications and Information Technology, POLITEHNICA University, Bucharest, majoring in "Microelectronics, Optoelectronics and Nanotechnologies" (2011), respectively "Microsystems" (2013). She obtained her doctorate in Physics – Optics in 2018 at the Faculty of Physics, University of Bucharest, Romania. Dr. Rebeca Tudor is scientific researcher at National Institute for Research and Development, IMT Bucharest, Romania, being part of the Laboratory of Micro and Nanophotonics since 2013. Her expertise is in the field of simulation, design, manufacturing and characterization of optical elements for optical and quantum communications. Also, Dr. Tudor is currently the director of postdoctoral grant of the Ministry of Research, Innovation and Digitization, CNCS – UEFISCDI, PN-III-P1-1.1-PD-2021-0399 Investigation of hybrid optical beams for optical and quantum communication (HYQOM). Dr. Tudor is the winner of the PATRIOTFEST 2019 edition (competition organized by the Romanian national security institutions).

Abstract:

Timing: 11:30:00-11:45:00 Paris Time (Presenter Local Time: 12:30:00-12:45:00)

Social, economic or cultural data must be transmitted from one point to another safely and secure. The photons are excellent candidates for optical communication since they can propagate over long distances but with very low loss, due to decoherence mechanism in free space. One can exploit many degrees of freedom of light in order to encode the information: time-bin, time-frequency, path encoding, amplitude, polarization, spatial structure - orbital angular momentum (OAM). Large alphabets (high capacity) and high security can be achieved when the information is encoded with OAM. Optical vortices which carry OAM propagate in straight line, so in case of obstacles between the transmitter and the receiver the information transfer is affected. On the other hand, Airy beams represent accelerating beams with curved trajectory and have been a subject of great interest for self-acceleration, self-healing, non-diffraction properties and robustness in case of the atmospheric turbulence during propagation. A promising solution for optical communication to preserve the information when are present line-of-sight obstacles (between transmitter and receiver) can be considered in bendable optical vortices (AOVs). These hybrid beams encompass both functions for OAM degree of freedom (to achieve high information capacity) and curved trajectory (to avoid obstacles). In this work, the generation of curved light beams is achieved by phase profile engineering with hybrid optical elements in order to improve free space optical communication. This approach has the big advantage that passive optical elements are not influenced by temperature and permits the implementation of compact optical systems. The investigation of encoding, propagation and decoding of AOV states will be investigated for a free space optical link.

Biography:

Malyutin Nickolay Dmitrievich – Doctor of Technical Sciences in the field of antennas and ultrahigh frequency devices. His main research interests include the theory of coupled strip lines, the analysis of coupled waves with significantly different phase velocities, as well as the development of microwave devices. The most significant scientific and practical achievements in the creation of broadband phase shifters with low losses, correctors of amplitude-frequency characteristics of electronic devices, stands and devices for measuring the vector parameters of microwave circuits in the pulsed mode of exposure have been obtained. Since 1996, Nickolay Malyutin has become a professor at Tomsk State University of Control Systems and Radio Electronics. Currently, he is engaged in solving problems of measuring non-reciprocal backscattering from electro-optical crystals and creation of quasi-chaotic microwave signals generators.

Abstract:

Timing: 11:00:00-11:15:00 Paris Time (Presenter Local Time: 16:00:00-16:15:00)

Electro-optical crystals of lithium niobate and other materials are widely used for the photonics devices manufacture. Their properties have been studied quite well in the optical wavelength ranges. We have undertaken an additional study of the properties of bulk lithium niobate crystals in the microwave range. The non-reciprocal properties of the backscattering of microwave waves with a frequency of 33 GHz from bulk lithium niobate crystals were investigated when ultrasonic vibrations with a frequency of 50 kHz were simultaneously exposed to the crystals. The measurements were carried out using an installation based on a Doppler locator. The conclusion is made about the possibility of applying the results obtained in the creation of Doppler frequency shift simulators, ultrasonic vibration sensors for contactless diagnostics of systems. In this paper, we report the results of an experimental study of the excitation of multiresonances in a device containing a bulk lithium niobate crystal as a dielectric filling of the upper half-plane of a coplanar strip transmission line. The research was carried out in the ultra-wide frequency band from 4 GHz to 26 GHz. The crystal was exposed to a linearly frequency-modulated quasi-T field of coplanar strip line. The modulus and phase of the transmission coefficient S21 and the reflection coefficient S11 were experimentally measured. The occurrence of quasi-chaotic oscillations S21, S11 due to the excitation of multiresonances in a strip structure containing a three-dimensional crystal was found. The examination of devices based on strip lines with bulk crystals was also carried out under the influence of pulsed signals. The occurrence of quasi-chaotic fluctuations was observed in this case as well. We have concluded that it is possible to create quasi-chaotic signal generators based on the detected effect for testing the electromagnetic compatibility of electronic systems.

Poster:

Biography:

Abstract:

Timing: 19:15:00-19:30:00 Paris Time (Presenter Local Time: 14:15:00-14:30:00)

Reumatoid Arthritis (RA) is a chronic inflammatory, autoimmune, sistemic and progressive disease that leads to irreversible destruction of cartilage and bone. In vivo and in vitro experimental studies using photobiomodulation therapy have shown positive effects on the modulation of factors that cause disease progression. The objective of this work was to evaluate the effects of photobiomodulation therapy in the treatment of induced Rheumatoid Arthritis (RA) in relation to biochemical and functional aspects. Methodology: Wistar rats were used, divided into groups, CTL (control), RA (Rheumatoid Arthritis), and RA + PBM. For the induction of RA, 3 injections of the lesion-induction solution (CIA) were used on days 1, 7 and 21 days after last induction. For groups that received PBM treatment (808 nm; 2J; 100mW) irradiation started immediately after the last induction. The strength (Fmax) and maximum deformation (Dmax) supported by the cartilage until the momento f rupture were evaluated. The quantification of the gene expression of MMPs 2, 9, 13 and TNF-α was performed. Results: the results of the evaluation of cell proliferation showed that the NT group showed a reduction in cell proliferation after 48 hours. PBM reduced the biomechanical changes caused by RA and the expression of MMPs 2, 9, 13 and TNF-α preventing disease progression. Conclusion: PBM promoted an improvement in the functional and biomechanical characteristics, reducing the impact on cartilage resistance and reducing the expression. Of MMPs. Suggesting that it is an important therapy in the treatment of rheumatoid arthritis with no known side effects. Key words: Photobiomodulation. Rheumatoid Arthritis. Metalloproteinases. Chondrocytes. Mechanical properties.

Poster:

Biography:

Giovanna Fontgalland Ferreira started her Bachelor's degree in Dentistry at University Nove de Julho (UNINOVE) in 2017. She started her career as a researcher in 2019, when she joined, as an undergrade, the area of Biophotonics. She also participated in academic leagues and assisted as a teacher's assistant in several disciplines as an undergraduate. In 2021 she completed a postgraduate degree in Biophotonics and Digital Dentistry. She is currently a researcher for the master's program at UNINOVE, in addition to working in the clinical area as a general practitioner, mainly performing minor oral surgery. In her spare time, she enjoys cooking and watching tv/streaming series. She is also particularly interested in music and art exhibitions.

Abstract:

Timing: 19:30:00-19:45:00 Paris Time (Presenter Local Time: 14:30:00-14:45:00)

Phobias and the general fear of dental procedures are both prevalent throughout the world, with local anesthesia being one of the procedures most feared by patients. For this reason, several complementary therapies have emerged with the aim of reducing the pain caused by the insertion of the needle and the need for repetition, but so far there is no defined protocol. Recent studies have shown that Photobiomodulation (PBM) is effective in controlling pain and increasing local microcirculation; these effects can help local anesthetic absorption, both enhancing its effect and decreasing the pain of the puncture. However, due to the scarcity of well-designed studies on this topic, further evidence of this is needed. This study’s aim will be to evaluate the ability of PBM to reduce puncture pain and increase local anesthetic effectiveness when used as a pre-anesthetic therapy. Accordingly, 50 subjects will participate in this double-blind, randomized controlled trial. The control group will be submitted to the standard anesthetic technique. The experimental group will have an infrared laser (100mW at 808nm, 9J at a single point) applied to the place where the puncture will be performed, immediately before anesthesia. The pterygomandibular technique will be conducted the same way in both groups by the same operator. The outcome assessor and the patient will be blinded to the application of PBM. The primary outcome of the study will be pain at the time of puncture, assessed using the visual analogue scale (VAS) at the time of needle insertion. Secondary outcomes which will be evaluated: anxiety through the Beck questionnaire and anesthetic latency through electric pulp test (timed until the onset of anesthetic action). Additionally, the amount of anesthetics needed to perform the procedure and the need for complementation will also be computed.

Poster:

Biography:

Abstract:

Timing: 19:45:00-20:00:00 Paris Time (Presenter Local Time: 14:45:00-15:00:00)

Peripheral nerves are constantly targets for injuries of different origins, whethertraumatic or chemical, and rarely recover without surgical intervention whenthey present tissue loss. These injuries are responsible for severalconsequences such as impaired mobility and sensitivity.During cancer treatment, whether for relief or cure, the patient may besubmitted to drug treatments that may present more severe side effects, othersmilder or even not present, one of these adverse effects is PeripheralNeuropathy, which begins through the hands and feet and gradually ascendthrough the arms and legs; sometimes you can feel tingling or numbness, othertimes it is like a twinge or a burning sensation or even increased sensitivity totemperature.Laser therapy, not being an invasive procedure, is very useful, although it canbe mentioned the increase in nerve function, increased metabolism of neuronsand increased production of myelin. Phototherapy applied transcutaneously,daily, from the first postoperative day onwards, significantly increases theincrease in the rate of axon regeneration.

Poster:

Biography:

Schuler, SSV is degree in dentistry from the Federal University of Paraíba, pediatric dentist and student of the postgraduate program at the UNINOVE in São Paulo.

Abstract:

Timing: 20:00:00-20:15:00 Paris Time (Presenter Local Time: 15:00:00-15:15:00)

The aim of this study is to evaluate a dosimetric parameter for aPDT in the endodontic treatment in deciduous teeth, considering bacterial reduction, clinical and radiographic. 20 anterior deciduous teeth with a diagnosis of pulp necrosis will be selected.The teeth will be randomly divided into two groups, which will receive treatments distinct: Group 1 (G1): conventional endodontic treatment (n=10); Group 2 (G2): Treatment with aPDT (9J) using optical fiber (N=10). For aPDT it will be used as a photosensitizer methylene blue (Chimiolux®) at a concentration of 0.005%, applied inside the canal radicular with a pre-irradiation time of 3 minutes, associated with the application of the laser with wavelength of 660nm (DMC, Laser THERAPY XT), the channel will be irradiated with the equipment previously calibrated with energy of 9J and power of 100mW. For microbiological analysis, two collections of the intracanal content will be carried out with paper cones, one before and another right after the proposed treatments in both groups. The radiographic aspects will be evaluated, considering the repair process, clinically will be evaluated: presence of fistula and mobility, the evaluations will be carried out in the periods of 1 and 3 months after the treatment. The data obtained will be submitted to the Shapiro-Wilk normality test, where defined for the statistical analysis that will be used for this study, adopting a significance level of 95% (p<0.05).

Poster: